Miyake Yoshiaki, Mitani Shigeru, Namba Yoshifumi, Umehara Norifumi, Kawamoto Toyohiro, Furuichi Shuro
Bone and Joint Surgery, Kawasaki Medical School, Kurashiki, JPN.
Cureus. 2024 Aug 13;16(8):e66805. doi: 10.7759/cureus.66805. eCollection 2024 Aug.
S-flurbiprofen (SFP) plaster, a non-steroidal anti-inflammatory drug preparation that penetrates effectively into deep tissue, is currently used as a conservative treatment for osteoarthritis. We investigated the analgesic and adverse effects of SFP plaster after total hip arthroplasty (THA).
A retrospective comparative study identified 100 patients who underwent primary THA in our department. Group A consisted of 50 patients who received the selective cyclooxygenase-2 inhibitor celecoxib for 14 days after surgery, while Group B consisted of 50 patients who received SFP plaster for 14 days after surgery. We noted the numerical rating pain intensity scale (NRS) score, body temperature, and adverse effects of the analgesics.
Groups A and B showed no significant difference in NRS scores (p > 0.05). The body temperature was significantly higher in Group B than in Group A on days one, two, three, and five (p < 0.01). In Group A, two patients (4%) showed drug-induced renal dysfunction, and one patient (2%) showed gastrointestinal disturbance. Patients in Group B showed no systemic or local adverse effects.
The application of SFP plaster after THA provided an analgesic effect similar to that obtained with oral celecoxib without causing obvious side effects. Applying an SFP plaster may be an effective solution for postoperative analgesia.
S-氟比洛芬（SFP）贴剂是一种能有效渗透至深层组织的非甾体类抗炎药制剂，目前用作骨关节炎的保守治疗方法。我们研究了全髋关节置换术（THA）后SFP贴剂的镇痛效果及不良反应。
一项回顾性对照研究纳入了在我科接受初次THA的100例患者。A组由50例术后接受选择性环氧化酶-2抑制剂塞来昔布治疗14天的患者组成，而B组由50例术后接受SFP贴剂治疗14天的患者组成。我们记录了数字疼痛强度量表（NRS）评分、体温及镇痛药的不良反应。
A组和B组的NRS评分无显著差异（p>0.05）。在术后第1、2、3和5天，B组的体温显著高于A组（p<0.01）。A组有2例患者（4%）出现药物性肾功能不全，1例患者（2%）出现胃肠道不适。B组患者未出现全身或局部不良反应。
THA后应用SFP贴剂提供了与口服塞来昔布相似的镇痛效果，且未引起明显副作用。应用SFP贴剂可能是术后镇痛的有效方法。
