Crain Nikhil A, Cohen Gail M, Ravish Matthew E, Skelton Joseph A
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Radiol Case Rep. 2024 Aug 27;19(11):5308-5312. doi: 10.1016/j.radcr.2024.07.183. eCollection 2024 Nov.
Rates of Blount disease and childhood obesity have increased in parallel, although the co-management of this acquired comorbidity and obesity is not well described. This report shares the course of a toddler with severe obesity who experienced rapid and persistent weight gain without success from nutrition and behavior changes. After repeat subspeciality evaluation, the patient was ultimately diagnosed with signs of early-onset Blount disease, urging the need for adjunct medical therapy. Initiation of topiramate was shown to achieve weight neutrality and improve the patient's body mass index (BMI), appearing to halt the progression of Blount disease and avoiding escalation to surgical treatment. This report suggests topiramate can be an effective and well-tolerated medication in young patients with a pressing need for weight intervention.
布朗特病的发病率与儿童肥胖率同步上升，尽管对于这种后天性合并症与肥胖症的联合管理尚无详尽描述。本报告分享了一名重度肥胖幼儿的病程，该幼儿体重快速持续增加，通过营养和行为改变未能成功减重。经过反复的专科评估，该患者最终被诊断出患有早发性布朗特病迹象，这促使需要辅助药物治疗。结果显示，使用托吡酯可实现体重持平并改善患者的体重指数（BMI），似乎能阻止布朗特病的进展并避免升级至手术治疗。本报告表明，对于迫切需要体重干预的年轻患者，托吡酯可能是一种有效且耐受性良好的药物。
