Rao Meenakshi, G Anju, Navriya Shiv Charan, Sureka Binit, Kudunthail Jeena Raju
Department of Pathology & Lab Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Department of Urology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
J Kidney Cancer VHL. 2024 Sep 10;11(3):59-64. doi: 10.15586/jkcvhl.v11i3.343. eCollection 2024.
Chromophobe renal cell carcinomas (ChRCCs) have a good prognosis and comprise approximately 5-7% of renal cell carcinomas (RCCs). The sarcomatoid differentiation in RCC is found in around 5-10% of cases; however, in ChRCC, it is much less than in other RCCs and poorly responds to chemotherapeutic agents. A study by de Peralta-Venturina et al. found 9% sarcomatoid differentiation in chromophobe RCC. We present the case of a 58-year-old female with a left abdominal mass diagnosed as ChRCC with the existence of sarcomatous differentiation including osteosarcomatous and chondrosarcomatous, which are of adverse prognosis. Osteosarcoma-like divergent differentiation in RCC is extremely rare, with limited documented cases. It should be carefully considered in evaluating and managing renal masses due to its potential impact on clinical outcomes.
嫌色性肾细胞癌（ChRCC）预后良好，约占肾细胞癌（RCC）的5%-7%。肾细胞癌中的肉瘤样分化见于约5%-10%的病例；然而，在嫌色性肾细胞癌中，其发生率远低于其他肾细胞癌，且对化疗药物反应不佳。de Peralta-Venturina等人的一项研究发现，嫌色性肾细胞癌中有9%存在肉瘤样分化。我们报告一例58岁女性，其左腹部肿块被诊断为伴有肉瘤样分化（包括骨肉瘤样和软骨肉瘤样分化）的嫌色性肾细胞癌，这些肉瘤样分化预后不良。肾细胞癌中骨肉瘤样异向分化极为罕见，文献记载的病例有限。由于其可能对临床结局产生影响，在评估和处理肾肿块时应仔细考虑。
