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母体壬基酚暴露对雄性子代小鼠大脑中神经胶质细胞增殖的影响。

Effects of maternal nonylphenol exposure on the proliferation of glial cells in the brain of male offspring mice.

作者信息

Lee Seung Hyun, Shin Hyun Seung, So Yun Hee, Lee Dong Hun, Kim Jin Yeop, Lee Eun-Hee, Jung Eui-Man

机构信息

Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan, Republic of Korea.

Institute for Future Earth, Pusan National University, Busan, Republic of Korea.

出版信息

Anim Cells Syst (Seoul). 2024 Sep 12;28(1):439-452. doi: 10.1080/19768354.2024.2401389. eCollection 2024.

DOI:10.1080/19768354.2024.2401389
PMID:39280932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11395876/
Abstract

Glial cells play a significant role in maintaining brain homeostasis and normal brain development, and their functions can be impaired by exposure to endocrine disruptors. 4-n-Nonylphenol (NP), a representative endocrine disruptor, is widely used in personal care products and industrial materials. NP accumulates in various organs, including the brain, of living organisms and adversely influences brain health. However, studies on the effects of NP on glial cells are limited. This study aims to investigate the effects of NP on glial cells using primary mixed glial cells and offspring mice exposed to NP during gestation and lactation. experiments revealed that NP exposure stimulated the astrocytes and microglia proliferation but not oligodendrocytes. NP exposure activated microglia and reduced myelin protein expression in oligodendrocytes. Moreover, maternal NP exposure increased the numbers of microglia and oligodendrocytes in the cerebral cortex of adult offspring. NP exposure caused anxiety- and depressive-like behaviors in adult mice. Collectively, these findings suggest that maternal NP exposure negatively affects the brain development in adult offspring mice.

摘要

神经胶质细胞在维持脑内环境稳定和正常脑发育中发挥着重要作用，而接触内分泌干扰物会损害其功能。4-正壬基酚（NP）是一种典型的内分泌干扰物，广泛应用于个人护理产品和工业材料中。NP在包括脑在内的生物体的各种器官中蓄积，并对脑健康产生不利影响。然而，关于NP对神经胶质细胞影响的研究有限。本研究旨在利用原代混合神经胶质细胞以及在妊娠和哺乳期接触NP的子代小鼠，来研究NP对神经胶质细胞的影响。实验表明，接触NP会刺激星形胶质细胞和小胶质细胞增殖，但不会刺激少突胶质细胞增殖。接触NP会激活小胶质细胞，并降低少突胶质细胞中髓磷脂蛋白的表达。此外，母体接触NP会增加成年子代小鼠大脑皮质中小胶质细胞和少突胶质细胞的数量。接触NP会导致成年小鼠出现焦虑样和抑郁样行为。总的来说，这些发现表明母体接触NP会对成年子代小鼠的脑发育产生负面影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/815f/11395876/2104e7345380/TACS_A_2401389_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/815f/11395876/c9a9325d110f/TACS_A_2401389_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/815f/11395876/1b11c6b0a5e5/TACS_A_2401389_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/815f/11395876/5213a86bd90e/TACS_A_2401389_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/815f/11395876/7c000de0cd2a/TACS_A_2401389_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/815f/11395876/1f46f1592974/TACS_A_2401389_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/815f/11395876/2104e7345380/TACS_A_2401389_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/815f/11395876/c9a9325d110f/TACS_A_2401389_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/815f/11395876/1b11c6b0a5e5/TACS_A_2401389_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/815f/11395876/5213a86bd90e/TACS_A_2401389_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/815f/11395876/7c000de0cd2a/TACS_A_2401389_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/815f/11395876/1f46f1592974/TACS_A_2401389_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/815f/11395876/2104e7345380/TACS_A_2401389_F0005_OC.jpg

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