Cheng Yuelei, Zhao Yunlai, Li Hao, Duan Minmin, Li Lianxiang, Zhou Song, Tang Qingbin, Xie Wei, Shi Jixue
Department of Emergency, Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Department of Emergency, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.
Toxicol Rep. 2024 Aug 28;13:101703. doi: 10.1016/j.toxrep.2024.101703. eCollection 2024 Dec.
Chlorfenapyr, an arylpyrrole-based insecticide, disrupts mitochondrial oxidative phosphorylation to deprive the target organism of energy. Chlorfenapyr poisoning in humans causes distinct clinical signs such as hyperhidrosis, malignant hyperthermia, rhabdomyolysis, and delayed neurological symptoms that worsen over time and can be fatal. When treating acute chlorfenapyr poisoning, physicians must consider the latent period and not assume that a patient is safe after an initial response to treatment. It is important to take measures before sudden, fatal symptoms appear. This paper presents three cases of chlorfenapyr poisoning as a warning for physicians to understand its clinical course and treatment.
氯虫苯甲酰胺，一种基于芳基吡咯的杀虫剂，会破坏线粒体氧化磷酸化过程，从而使目标生物体丧失能量。人类氯虫苯甲酰胺中毒会引发明显的临床症状，如多汗、恶性高热、横纹肌溶解以及随着时间推移会恶化且可能致命的迟发性神经症状。治疗急性氯虫苯甲酰胺中毒时，医生必须考虑潜伏期，不能认为患者在对治疗有初步反应后就安全了。在突然出现致命症状之前采取措施很重要。本文介绍了三例氯虫苯甲酰胺中毒病例，以警示医生了解其临床病程和治疗方法。
