[利用分析离子显微镜对稳定碘和放射性碘在甲状腺泡和细胞中分布的动力学研究]
[Kinetic study of the distribution of stable iodine and radioiodine in the thyroid vesicle and cell using analytical ionic microscopy].
作者信息
Larras-Regard E, Siami K
出版信息
C R Acad Sci III. 1985;301(6):329-34.
PMID:3928109
Abstract
Images of the distribution of 127I and 129I have been obtained by means of SIMS, in Mouse thyroid gland, after tracer injection. Profiles analysis performed on 60 microns area express the relative amount of iodine in thyroid vesicles. Isotopic ratio show a large discrepancy from a follicle to an other which is in situ in agreement with the functional heterogeneity of the gland. The interest of the method to study the kinetics of iodine pools is discussed.
摘要
通过二次离子质谱法（SIMS），在给小鼠注射示踪剂后，已获取了小鼠甲状腺中¹²⁷I和¹²⁹I分布的图像。对60微米区域进行的轮廓分析显示了甲状腺泡中碘的相对含量。同位素比率显示，从一个滤泡到另一个滤泡存在很大差异，这与甲状腺的功能异质性在原位情况相符。本文讨论了该方法在研究碘库动力学方面的意义。
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