八种氨基酸对胰腺外分泌和内分泌功能的影响。

Effects of eight amino acids on the exocrine and endocrine pancreatic function.

作者信息

Saitoh Y, Honda T, Matsuno S, Noto N, Miyashita E, Sato T

出版信息

Tohoku J Exp Med. 1979 Nov;129(3):257-72.

Abstract

Eight amino acids were intravenously administered in a dose of 2 mmoles/kg/hr to dogs with chronic pancreatic fistula, and the effect of each amino acid on endocrine and exocrine pancreatic secretions was investigated. Asparagine, arginine, isoleucine and phenylalanine administered under the stimulation of secretin-pancreozymin significantly inhibited the secretion of pancreatic juice by 23%, 15%, 13% and 13%, and the output of amylase by 53%, 37%, 27% and 18%, respectively. Threonine, glycine or methionine brought about no significant changes in pancreatic secretion, but valine significantly increased pancreatic juice secretion by 13% and amylase output by 15%. Any of the eight amino acids caused no noticeable change in the concentration of bicarbonate.

摘要

以2毫摩尔/千克/小时的剂量向患有慢性胰瘘的狗静脉注射8种氨基酸，并研究每种氨基酸对胰腺内分泌和外分泌的影响。在促胰液素-缩胆囊素的刺激下给予天冬酰胺、精氨酸、异亮氨酸和苯丙氨酸，可显著抑制胰液分泌，分别降低23%、15%、13%和13%，淀粉酶分泌分别降低53%、37%、27%和18%。苏氨酸、甘氨酸或蛋氨酸对胰腺分泌无显著影响，但缬氨酸可使胰液分泌显著增加13%，淀粉酶分泌增加15%。这8种氨基酸中的任何一种对碳酸氢盐浓度均无明显影响。