Hussein Mousa, Thomas Merlin, Al-Tikrity Mustafa, Elarabi Anam, Hameed Mansoor, Al-Adab Aisha, Ibrahim Wanis, Chandra Prem, Ahmed Shakeel, Muslim Muhammad, Al-Qahoush Osaid, Raza Tasleem
Pulmonology Department, Hamad Medical Corporation, Doha, Qatar.
Department of Clinical Medicine, Qatar University, Doha, Qatar.
IJID Reg. 2024 Aug 14;12:100425. doi: 10.1016/j.ijregi.2024.100425. eCollection 2024 Sep.
Exudative pleural effusions have a broad etiology and usually necessitate further investigative workup, including invasive procedures. This study aimed to evaluate and compare the demographic, clinical, and biochemical characteristics of tuberculous, malignant, and chronic inflammatory pleural effusions.
This is a 2-year prospective cohort study of patients referred for medical thoracoscopy with an exudative pleural effusion.
A total of 159 patients were enrolled in the study, with a mean age of 42.49 ± 13.8 years and the majority being males 121 (76.1%). As expected, patients with tuberculous effusions were significantly younger than those with non-tuberculous effusions (37.7 ± 10.9 vs 49.1 ± 14.9, <0.001). Serum analysis showed significantly lower white blood cell count (7.5 × 10/L ± 2.7 vs 9.0 × 10/L ± 3.3, = 0.004), higher total protein (76.2 g/dL ± 10.1 vs 70.2 g/dL ± 8.9, <0.001), and higher median C-reactive protein (median 77.5, interquartile range 51-116 vs median 40.5, interquartile range 8-127, <0.001) among tuberculous compared with non-tuberculosis effusions.
Our study validates previous findings showing similar results in patients with tuberculous pleural effusions. A predictive model incorporating different demographic and clinical/laboratory characteristics may be useful in the early etiologic characterization of exudative pleural effusion.
渗出性胸腔积液病因广泛，通常需要进一步的检查评估，包括侵入性操作。本研究旨在评估和比较结核性、恶性和慢性炎症性胸腔积液的人口统计学、临床和生化特征。
这是一项为期2年的前瞻性队列研究，研究对象为因渗出性胸腔积液而接受内科胸腔镜检查的患者。
共有159例患者纳入本研究，平均年龄为42.49±13.8岁，大多数为男性，共121例（76.1%）。正如预期的那样，结核性胸腔积液患者明显比非结核性胸腔积液患者年轻（37.7±10.9岁 vs 49.1±14.9岁，<0.001）。血清分析显示，与非结核性胸腔积液相比，结核性胸腔积液患者的白细胞计数显著降低（7.5×10⁹/L±2.7 vs 9.0×10⁹/L±3.3，P = 0.004），总蛋白水平更高（76.2 g/dL±10.1 vs 70.2 g/dL±8.9，P<0.001），C反应蛋白中位数更高（中位数77.5，四分位间距51 - 116 vs 中位数40.5，四分位间距8 - 127，P<0.001）。
我们的研究证实了先前的研究结果，即结核性胸腔积液患者有相似的表现。一个纳入不同人口统计学和临床/实验室特征的预测模型可能有助于渗出性胸腔积液的早期病因诊断。
