Porwal Ashwin D, Gandhi Paresh M, Kulkarni Deepak K, Bhagwat Gajanan B, Kamble Pravin P
Department of Proctology, Healing Hands Clinic, Mahārāshtra, Pune 411001, India.
R&D Center, Healing Hands and Herbs Pvt. Ltd., Mahārāshtra, Pune 411002, India.
World J Gastrointest Pharmacol Ther. 2024 Sep 5;15(5):97330. doi: 10.4292/wjgpt.v15.i5.97330.
Functional constipation (FC) is a common gastrointestinal disorder characterized by abdominal pain and bloating, which can greatly affect the quality of life of patients. Conventional treatments often yield suboptimal results, leading to the exploration of alternative therapeutic approaches.
To evaluate the efficacy of KiwiBiotic in the management of FC and related symptoms.
This prospective, interventional, single-center, crossover study compared the safety and effectiveness of KiwiBiotic psyllium husk in managing FC, abdominal pain, and bloating. Participants diagnosed with FC were randomly assigned to receive KiwiBiotic or psyllium husk during the two treatment periods, with a 14-day washout period between them.
Seventy participants were enrolled, 32 of whom received KiwiBiotic followed by psyllium husk, and 33 received KiwiBiotic. KiwiBiotic showed superiority over psyllium husk in alleviating abdominal pain and bloating, as evidenced by significantly lower mean scores. Furthermore, KiwiBiotic resulted in more than 90.0% of patients experiencing relief from various constipation symptoms, while psyllium husk showed comparatively lower efficacy.
KiwiBiotic is an effective treatment option for FC, abdominal pain, and bloating, highlighting its potential as a promising alternative therapy for patients with FC and its associated symptoms.
功能性便秘（FC）是一种常见的胃肠道疾病，其特征为腹痛和腹胀，会极大影响患者的生活质量。传统治疗方法往往效果欠佳，因此人们开始探索其他治疗方法。
评估奇异益生元对功能性便秘及相关症状的治疗效果。
这项前瞻性、干预性、单中心、交叉研究比较了奇异益生元与洋车前子壳在治疗功能性便秘、腹痛和腹胀方面的安全性和有效性。被诊断为功能性便秘的参与者在两个治疗期内随机分配接受奇异益生元或洋车前子壳治疗，两个治疗期之间有14天的洗脱期。
共招募了70名参与者，其中32人先接受奇异益生元治疗，后接受洋车前子壳治疗，33人仅接受奇异益生元治疗。奇异益生元在缓解腹痛和腹胀方面优于洋车前子壳，平均得分显著更低。此外，超过90.0%的患者服用奇异益生元后各种便秘症状得到缓解，而洋车前子壳的疗效相对较低。
奇异益生元是治疗功能性便秘、腹痛和腹胀的有效选择，凸显了其作为功能性便秘及其相关症状患者一种有前景的替代疗法的潜力。
