Caballero Noemi, Benslaiman Bouchra, Ansell Juliet, Serra Jordi
Motility and Functional Gut Disorders Unit, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), University Hospital Germans Trias i Pujol, Badalona, Spain.
Department of Medicine, Autonomous University of Barcelona, Badalona, Spain.
Neurogastroenterol Motil. 2020 Sep;32(9):e13874. doi: 10.1111/nmo.13874. Epub 2020 May 20.
Green kiwifruit is a fiber-rich fruit that has been shown effective for treatment of constipation. However, fermentation of fibers by colonic bacteria may worsen commonly associated gas-related abdominal symptoms.
To determine the effect of green kiwifruit on transit and tolerance to intestinal gas in humans.
In 11 healthy individuals, two gas challenge tests were performed (a) after 2 weeks on a low-flatulogenic diet and daily intake of 2 green kiwifruits and (b) after 2 weeks on a similar diet without intake of kiwifruits. The gas challenge test consisted in continuous infusion of a mixture of gases into the jejunum at 12 mL/min for 2 hours while measuring rectal gas evacuation, abdominal symptoms, and abdominal distension. During the 2 weeks prior to each gas challenge test (on-kiwifruit and off-kiwifruit), the number and consistency of stools, and abdominal symptoms were registered.
Intake of kiwifruits was associated with more bowel movements per day (1.8 ± 0.1 vs 1.5 ± 0.1 off-kiwifruit; P = .001) and somewhat looser stools (Bristol score 3.3 ± 0.2 vs 2.8 ± 0.1 off-kiwifruit; P = .072) without relevant abdominal symptoms. Gas infusion produced similar gas evacuation (1238 ± 254 mL and 1172 ± 290 mL; P = .4355), perception of symptoms (score 1.2 ± 0.2 and 1.3 ± 0.3; P = .2367), and abdominal distension (17 ± 7 mm and 17 ± 6 mm; P = .4704) while on-kiwifruit or off-kiwifruit.
In healthy subjects, green kiwifruit increases stool frequency without relevant effects on intestinal gas transit and tolerance. If confirmed in patients, these fruits may provide a natural and well-tolerated treatment alternative for constipation.
绿奇异果是一种富含纤维的水果，已被证明对治疗便秘有效。然而，结肠细菌对纤维的发酵可能会使常见的与气体相关的腹部症状恶化。
确定绿奇异果对人体肠道转运和对肠道气体耐受性的影响。
对11名健康个体进行了两项气体激发试验，（a）在低产气饮食并每日摄入2个绿奇异果2周后进行，（b）在类似饮食但不摄入奇异果2周后进行。气体激发试验包括以12毫升/分钟的速度向空肠持续输注混合气体2小时，同时测量直肠排气、腹部症状和腹胀情况。在每次气体激发试验前的2周内（食用奇异果期间和不食用奇异果期间），记录大便的次数和稠度以及腹部症状。
食用奇异果与每天排便次数增加有关（食用奇异果时为1.8±0.1次，不食用奇异果时为1.5±0.1次；P = 0.001），大便稍稀（布里斯托大便分类法评分食用奇异果时为3.3±0.2，不食用奇异果时为2.8±0.1；P = 0.072），且无相关腹部症状。在食用奇异果或不食用奇异果期间，气体输注产生的排气量相似（分别为1238±254毫升和1172±290毫升；P = 0.4355）、症状感知相似（评分分别为1.2±0.2和1.3±0.3；P = 0.2367）以及腹胀程度相似（分别为17±7毫米和17±6毫米；P = 0.4704）。
在健康受试者中，绿奇异果可增加排便频率，而对肠道气体转运和耐受性无相关影响。如果在患者中得到证实，这些水果可能为便秘提供一种天然且耐受性良好的治疗选择。
