Wertelecki W, Iinuma K, Bentley H P
Cancer Genet Cytogenet. 1985 Sep;18(1):87-9. doi: 10.1016/0165-4608(85)90043-3.
In a family with neurofibromatosis, an affected 16-year-old male developed undifferentiated lymphoma that evolved into acute lymphocytic leukemia. Five years later, his 7-month-old nephew with neurofibromatosis developed a prostatic embryonal rhabdomyosarcoma. This illustrates familial neurofibromatosis complicated by non-neural malignancy in relatives.
在一个患有神经纤维瘤病的家族中,一名16岁的患病男性患上了未分化淋巴瘤,后演变成急性淋巴细胞白血病。五年后,他患有神经纤维瘤病的7个月大的侄子患上了前列腺胚胎性横纹肌肉瘤。这说明了家族性神经纤维瘤病在亲属中并发非神经恶性肿瘤的情况。