Pumrod Supakrit, Akkarawatkhoosith Nattee, Kaewchada Amaraporn, Tongtummachat Tiprawee, Andrew Lin Kun-Yi, Jaree Attasak
Center of Excellence on Petrochemical and Materials Technology, Department of Chemical Engineering, Faculty of Engineering, Kasetsart University Chatuchak Bangkok Thailand
Department of Chemical Engineering, Faculty of Engineering, Mahidol University Nakhon Pathom Thailand.
RSC Adv. 2024 Sep 12;14(40):29014-29023. doi: 10.1039/d4ra05816j.
DFF's diverse applications in pharmaceuticals, fungicides, and polymer synthesis motivate the development of efficient production methods. This study reports the continuous-flow synthesis of DFF from 5-HMF in a packed-bed reactor. The Box-Behnken design coupled with response surface methodology (RSM) was employed to optimize the reaction parameters (catalyst, solvent, temperature, oxygen flow rate, catalyst amount) for DFF yield. Ru/AlO in toluene proved to be the most effective catalyst-solvent combination. The optimal conditions for DFF production were identified as: 140 °C reaction temperature, 10 ml min oxygen flow rate, and 0.15 g catalyst loading. Under these conditions, a DFF yield of 84.2% was achieved.
二氟甲氧基苯（DFF）在制药、杀菌剂和聚合物合成中的多种应用推动了高效生产方法的发展。本研究报道了在填充床反应器中由5-羟甲基糠醛（5-HMF）连续流合成DFF。采用Box-Behnken设计结合响应面法（RSM）来优化反应参数（催化剂、溶剂、温度、氧气流速、催化剂量）以提高DFF产率。结果表明，甲苯中的Ru/AlO是最有效的催化剂-溶剂组合。确定的DFF生产最佳条件为：反应温度140℃、氧气流速10 ml/min、催化剂负载量0.15 g。在这些条件下，DFF产率达到了84.2%。
