Ducrocq Julie, Lévesque Benoit, De Serres Gaston, Boiteau Véronique, Yansouni Cedric P, Proulx Jean-François, Talbot Denis
Département de médecine sociale et préventive, Université Laval, Québec, Québec, Canada.
Axe Santé des populations et pratiques optimales en santé, Centre Hospitalier Universitaire de Québec, Québec, Québec, Canada.
Int J Circumpolar Health. 2024 Dec;83(1):2398864. doi: 10.1080/22423982.2024.2398864. Epub 2024 Sep 16.
is a bacterium that may colonise and proliferate in human stomachs, leading invariably to chronic inflammation and, to a lesser extent, to peptic ulcers and cancer. The main objective of this study is to describe the epidemiology surrounding in Nunavik's Inuit population using the 2004 and 2017 Health Surveys. Estimated prevalences were 70.9% for bacterial colonisation using a stool antigens test (SAT), 72.5% for anti- antibodies, 12.7% for faecal occult blood in participants aged ≥ 50 and respectively of 28.4%, 11.2% and 2.4% for a prior diagnosis of colonisation, gastritis and peptic ulcer in the medical charts, with under five cases of gastric cancer reported. Variables associated with higher SAT+ prevalence were the number of household members (prevalence ratio [PR] = 1.03) and age (quadratic relationship), whereas mainly drinking municipal (PR = 0.84) and natural water (PR = 0.72) compared to bottled water, and increasing alcohol consumption (PR = 0.96) were associated with reduced prevalence. Despite current regional guidelines targeting high risk individuals in the context of high prevalence, Nunavik's health authorities must remain vigilant by following gastric cancer incidence and the rapid evolution of guidelines, while considering local realities.
是一种可能在人类胃部定植并增殖的细菌,必然会导致慢性炎症,并在较小程度上导致消化性溃疡和癌症。本研究的主要目的是利用2004年和2017年健康调查描述努纳维克因纽特人群中围绕该细菌的流行病学情况。使用粪便抗原检测(SAT)的细菌定植估计患病率为70.9%,抗抗体患病率为72.5%,50岁及以上参与者的粪便潜血患病率为12.7%,病历中既往诊断为定植、胃炎和消化性溃疡的患病率分别为28.4%、11.2%和2.4%,报告的胃癌病例不足5例。与SAT+患病率较高相关的变量是家庭成员数量(患病率比[PR]=1.03)和年龄(二次关系),而与瓶装水相比,主要饮用市政供水(PR=0.84)和天然水(PR=0.72)以及饮酒量增加(PR=0.96)与患病率降低相关。尽管目前的地区指南针对高患病率背景下的高危个体,但努纳维克的卫生当局必须通过跟踪胃癌发病率和指南的快速演变并考虑当地实际情况来保持警惕。