Isenlik Bekir Sitki, Sayal Hasan Berkan, Kaygun Bilgesu Cetinel, Turk Merve, Inal Hasan Ali
Department of Obstetrics and Gynecology, Antalya Training and Research Hospital, Antalya, Turkey.
Department of Perinathology, Antalya Training and Research Hospital, Antalya, Turkey.
J Clin Ultrasound. 2025 Jan;53(1):52-60. doi: 10.1002/jcu.23825. Epub 2024 Sep 16.
To compare the effects of nifedipine and indomethacin, used for tocolytic purposes in the treatment of preterm labor (PTL), on fetal-maternal Doppler blood flows and perinatal outcomes.
Eighty pregnant women between weeks 24 and 32 of gestation who used nifedipine (n = 40) and indomethacin (n = 40) as tocolytic treatments due to PTL were prospectively and consecutively included in the study. Sociodemographic, obstetric, and laboratory and Doppler flow parameters were compared between the groups.
Statistically significant differences were observed between the groups in terms of gestational age at delivery and birth weight, Doppler flows (umbilical artery (UA) Pulsatility Index (PI), and UA Resistance Index (RI)) at 12, 24, and 48 h, middle cerebral artery RI at 12 h, and ductus venosus (DV) PI and DV-RI at 12, 24, and 48 h (p < 0.05).
The findings of this study showed that nifedipine and indomethacin used in the treatment of PTL had significant effects on UA-PI and UA-RI Doppler flows at 12, 24, and 24 h, MCA-RI Doppler flows at 12 h, and DV-PI and DV-RI Doppler flows at 12, 24, and 48 h. Further studies involving larger numbers of participants are now needed to support these results.
比较硝苯地平与吲哚美辛用于治疗早产（PTL）的保胎目的时，对母婴多普勒血流及围产期结局的影响。
前瞻性连续纳入80例妊娠24至32周因PTL使用硝苯地平（n = 40）和吲哚美辛（n = 40）进行保胎治疗的孕妇。比较两组的社会人口统计学、产科、实验室及多普勒血流参数。
两组在分娩时的孕周、出生体重、12、24和48小时的多普勒血流（脐动脉（UA）搏动指数（PI）和UA阻力指数（RI））、12小时的大脑中动脉RI以及12、24和48小时的静脉导管（DV）PI和DV-RI方面存在统计学显著差异（p < 0.05）。
本研究结果表明，用于治疗PTL的硝苯地平和吲哚美辛对12、24和24小时的UA-PI和UA-RI多普勒血流、12小时的MCA-RI多普勒血流以及12、24和48小时的DV-PI和DV-RI多普勒血流有显著影响。现在需要进一步开展涉及更多参与者的研究来支持这些结果。
