Wager Annalisa C, Springer Cary, Bergee Rebecca, Craig Linden E
The University of Tennessee, Knoxville, TN.
Vet Pathol. 2025 Jan;62(1):37-41. doi: 10.1177/03009858241279135. Epub 2024 Sep 16.
Sarcoma samples from 33 dogs, 25 subcutaneous and 8 articular, were submitted for cytokeratin immunohistochemistry. Eight of the 25 subcutaneous sarcomas (32%) expressed cytokeratin in 1% to 50% of the neoplastic cells. Of the 7 articular sarcomas evaluated, 1 (14%) expressed cytokeratin in 10% of neoplastic cells. The Kaplan-Meier survival analysis showed that the mean overall survival of dogs with subcutaneous sarcomas (28.1 months [confidence interval [CI]:17.8, 38.4]) did not significantly differ from those with articular sarcomas (24.8 months [CI = 0.5, 29.0]). Overall survival of dogs with sarcomas (both locations combined) immunoreactive for cytokeratin (31.2 months [CI = 17.8, 44.6]) did not differ from those not immunoreactive for cytokeratin (22.0 months [CI = 8.4, 35.6]). Therefore, cytokeratin expression does not indicate synovial origin ( = .64) and neither sarcoma location ( = .76) nor cytokeratin expression ( .53) affects patient overall survival in this small study. The use of cytokeratin immunohistochemistry is not helpful to determine synovial origin of sarcomas in dogs.
33只犬的肉瘤样本（25个皮下肉瘤和8个关节肉瘤）被送去做细胞角蛋白免疫组织化学检测。25个皮下肉瘤中有8个（32%）在1%至50%的肿瘤细胞中表达细胞角蛋白。在评估的7个关节肉瘤中，1个（14%）在10%的肿瘤细胞中表达细胞角蛋白。Kaplan-Meier生存分析显示，皮下肉瘤犬的平均总生存期（28.1个月[置信区间[CI]：17.8，38.4]）与关节肉瘤犬的平均总生存期（24.8个月[CI = 0.5，29.0]）无显著差异。细胞角蛋白免疫反应阳性的肉瘤犬（两个部位合并）的总生存期（31.2个月[CI = 17.8，44.6]）与细胞角蛋白免疫反应阴性的肉瘤犬（22.0个月[CI = 8.4，35.6]）无差异。因此，细胞角蛋白表达并不表明滑膜起源（P = 0.64），在这项小型研究中，肉瘤部位（P = 0.76）和细胞角蛋白表达（P = 0.53）均不影响患者的总生存期。细胞角蛋白免疫组织化学检测无助于确定犬肉瘤的滑膜起源。
