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老年心血管疾病的预防

[Cardiovascular prevention in old age].

作者信息

Müller-Werdan Ursula, Rosada Adrian, Norman Kristina

机构信息

Medizinische Klinik für Geriatrie und Altersmedizin, Charité - Universitätsmedizin Berlin, Reinickendorfer Straße 21, 13347, Berlin, Deutschland.

Evangelisches Geriatriezentrum Berlin gGmbH, Berlin, Deutschland.

出版信息

Z Gerontol Geriatr. 2024 Oct;57(6):447-451. doi: 10.1007/s00391-024-02355-8. Epub 2024 Sep 16.

DOI:10.1007/s00391-024-02355-8
PMID:39283336
Abstract

The enormous potential of cardiovascular prevention in terms of expanding the life span and health span is presently nowhere near being realized. The five classical cardiovascular risk factors body mass index (BMI), systolic blood pressure, non-high-density lipoprotein (non-HDL) cholesterol, tobacco smoking, and diabetes mellitus account for more than half of the cases of incident cardiovascular diseases. Cardiovascular prevention is also effective and adequate in seemingly healthy individuals aged 70 years or above, although the association of several cardiovascular risk factors with cardiovascular diseases is less pronounced in old age. The cardiovascular risk of seemingly healthy persons aged 70 years or above can validly be determined using the Systematic COronary Risk Evaluation-Older Persons (SCORE2-OP), leading to risk-adjusted clear treatment recommendations. National and international guidelines advocate individualized cardiovascular prevention in several domains including diet, physical activity and risk factor management through to old age.

摘要

心血管预防在延长寿命和健康寿命方面具有巨大潜力,但目前远未实现。五个经典的心血管危险因素,即体重指数(BMI)、收缩压、非高密度脂蛋白(non-HDL)胆固醇、吸烟和糖尿病,占心血管疾病发病病例的一半以上。心血管预防对70岁及以上看似健康的个体也有效且充分,尽管一些心血管危险因素与心血管疾病的关联在老年时不太明显。使用老年人系统性冠状动脉风险评估(SCORE2-OP)可以有效地确定70岁及以上看似健康者的心血管风险,从而得出经过风险调整的明确治疗建议。国家和国际指南提倡在包括饮食、体育活动和危险因素管理直至老年的多个领域进行个体化心血管预防。

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本文引用的文献

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Human trials exploring anti-aging medicines.探索抗衰老药物的人体试验。
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Lifetime risks of cardiovascular disease.心血管疾病的终身风险。
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