Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Adv Anat Embryol Cell Biol. 2024;239:157-197. doi: 10.1007/978-3-031-62232-8_7.
Maternal nutrition and metabolic health status during pregnancy are critical factors that shape the life-long health trajectory of offspring. Altered nutrition during specific times of development in utero can lead to functional changes in tissues such as the pancreatic β-cells, predisposing those tissues to metabolic diseases and Type 2 diabetes that manifest later in life. This chapter will focus on the role of pregnancy complications with altered nutrition during gestation in the maladaptive programming of β-cell mass and function in the offspring.
孕产妇营养和代谢健康状况是影响后代终生健康轨迹的关键因素。宫内特定发育时期的营养改变可导致胰腺β细胞等组织发生功能变化，使这些组织易患成年后发生的代谢性疾病和 2 型糖尿病。本章将重点讨论妊娠期营养改变导致的妊娠并发症在后代β细胞数量和功能适应性编程中的作用。
