Department of Nephrology, the Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
Gastric Cancer. 2024 Nov;27(6):1348-1349. doi: 10.1007/s10120-024-01554-x. Epub 2024 Sep 16.
The article by Shin et al. provides valuable insights into the correlation between the gastric mucosa-associated gastric microbiome (MAM) and metachronous recurrence. However, the use of the Cox proportional hazards model in their analysis presents several limitations. The study may result in mixed censoring outcomes, and the assumption of constant hazard ratios over time may not hold. Considering these limitations, future research should adopt alternative approaches, such as the accelerated failure time (AFT) model, to provide a more comprehensive understanding of the relationship between gastric MAM and metachronous recurrence.
申等人的文章提供了关于胃黏膜相关胃微生物组（MAM）与异时性复发之间相关性的有价值的见解。然而，他们在分析中使用 Cox 比例风险模型存在几个局限性。该研究可能导致混合删失结果，并且随着时间的推移，风险比恒定的假设可能不成立。考虑到这些限制，未来的研究应采用替代方法，如加速失效时间（AFT）模型，以更全面地了解胃 MAM 与异时性复发之间的关系。
