-二氟环丙烯基酮的不对称转移氢化反应：对映体富集的-二氟环丙基酮的合成与官能团化
Asymmetric Transfer Hydrogenation of -Difluorocyclopropenyl Ketones: The Synthesis and Functionalization of Enantioenriched -Difluorocyclopropyl Ketones.
作者信息
Charron Olivier, Kosiuha Marharyta, Phansavath Phannarath, Ratovelomanana-Vidal Virginie, Gontard Geoffrey, Meyer Christophe
机构信息
Molecular, Macromolecular Chemistry, and Materials, ESPCI Paris-PSL, CNRS, 10 rue Vauquelin, 75005 Paris, France.
Chimie ParisTech, CNRS, Institute of Chemistry for Life and Health Sciences, CSB2D Team, PSL University, 11 rue Pierre et Marie Curie, 75005 Paris, France.
出版信息
J Org Chem. 2024 Oct 4;89(19):14073-14080. doi: 10.1021/acs.joc.4c01497. Epub 2024 Sep 16.
The asymmetric transfer hydrogenation of -difluorocyclopropenyl ketones, catalyzed by a Noyori-Ikariya ruthenium complex, was developed to access substituted optically enriched -disubstituted -difluorocyclopropyl ketones, and the value of these latter building blocks was illustrated by the synthesis of heterocycles fused to the difluorocyclopropyl moiety.
开发了一种由野依-池谷钌配合物催化的α,α-二氟环丙烯基酮的不对称转移氢化反应，以制备取代的光学富集的α,α-二取代-α,α-二氟环丙基酮，并且通过合成与二氟环丙基部分稠合的杂环来说明这些后一种结构单元的价值。
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