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SGLT2 inhibitors and GLP-1 receptor agonists: which is the best anti-frailty drug?

作者信息

Mone Pasquale, Ciccarelli Michele, Jankauskas Stanislovas S, Guerra Germano, Vecchione Carmine, Visco Valeria, Santulli Gaetano

机构信息

Department of Medicine and Health Sciences "Vincenzo Tiberio", Campobasso 86100, Italy; Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Einstein Institute for Neuroimmunology and Inflammation (INI), Fleischer Institute for Diabetes and Metabolism (FIDAM), Albert Einstein College of Medicine, New York, NY, USA; Casa di Cura Montevergine, Mercogliano (Avellino), Italy.

Department of Medicine, Surgery, and Dentistry, University of Salerno, Baronissi (Salerno), Italy.

出版信息

Lancet Healthy Longev. 2024 Sep;5(9):100632. doi: 10.1016/j.lanhl.2024.08.001. Epub 2024 Sep 13.

DOI:10.1016/j.lanhl.2024.08.001
PMID:39284335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11472278/
Abstract
摘要

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本文引用的文献

1
Effect of frailty on effectiveness and safety of GLP-1 receptor agonists versus SGLT2 inhibitors in people with type 2 diabetes in Taiwan: a retrospective, nationwide, longitudinal study.在台湾，衰弱对 2 型糖尿病患者 GLP-1 受体激动剂与 SGLT2 抑制剂有效性和安全性的影响：一项回顾性、全国性、纵向研究。
Lancet Healthy Longev. 2024 Sep;5(9):100621. doi: 10.1016/j.lanhl.2024.07.004. Epub 2024 Sep 13.
2
Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes.司美格鲁肽对 2 型糖尿病患者慢性肾脏病的影响。
N Engl J Med. 2024 Jul 11;391(2):109-121. doi: 10.1056/NEJMoa2403347. Epub 2024 May 24.
3
Comparative Cardiovascular Effectiveness and Safety of SGLT-2 Inhibitors, GLP-1 Receptor Agonists, and DPP-4 Inhibitors According to Frailty in Type 2 Diabetes.根据 2 型糖尿病患者的虚弱情况比较 SGLT-2 抑制剂、GLP-1 受体激动剂和 DPP-4 抑制剂的心血管有效性和安全性。
Diabetes Care. 2023 Nov 1;46(11):2004-2014. doi: 10.2337/dc23-0671.
4
Functional and Clinical Importance of SGLT2-inhibitors in Frailty: From the Kidney to the Heart.SGLT2 抑制剂在虚弱中的功能和临床重要性：从肾脏到心脏。
Hypertension. 2023 Sep;80(9):1800-1809. doi: 10.1161/HYPERTENSIONAHA.123.20598. Epub 2023 Jul 5.
5
Metabolic Impact of Frailty Changes Diabetes Trajectory.衰弱的代谢影响改变糖尿病病程。
Metabolites. 2023 Feb 16;13(2):295. doi: 10.3390/metabo13020295.
6
The real-world safety profile of sodium-glucose co-transporter-2 inhibitors among older adults (≥ 75 years): a retrospective, pharmacovigilance study.钠-葡萄糖共转运蛋白 2 抑制剂在老年患者（≥75 岁）中的真实世界安全性：一项回顾性、药物警戒学研究。
Cardiovasc Diabetol. 2023 Jan 24;22(1):16. doi: 10.1186/s12933-023-01743-5.
7
SGLT2 Inhibition via Empagliflozin Improves Endothelial Function and Reduces Mitochondrial Oxidative Stress: Insights From Frail Hypertensive and Diabetic Patients.恩格列净通过抑制 SGLT2 改善内皮功能并减少线粒体氧化应激：来自衰弱的高血压和糖尿病患者的见解。
Hypertension. 2022 Aug;79(8):1633-1643. doi: 10.1161/HYPERTENSIONAHA.122.19586. Epub 2022 Jun 15.
8
Empagliflozin Improves Cognitive Impairment in Frail Older Adults With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction.恩格列净可改善伴有射血分数保留的心力衰竭的 2 型糖尿病虚弱老年患者的认知障碍。
Diabetes Care. 2022 May 1;45(5):1247-1251. doi: 10.2337/dc21-2434.
9
Dapagliflozin in Patients with Chronic Kidney Disease.达格列净治疗慢性肾脏病患者。
N Engl J Med. 2020 Oct 8;383(15):1436-1446. doi: 10.1056/NEJMoa2024816. Epub 2020 Sep 24.
10
Frailty in elderly people.老年人虚弱。
Lancet. 2013 Mar 2;381(9868):752-62. doi: 10.1016/S0140-6736(12)62167-9. Epub 2013 Feb 8.