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GLP-1 receptor agonists and SGLT2 inhibitors: new anti-aging tools?

作者信息

Santulli Gaetano, Mone Pasquale, Varzideh Fahimeh

机构信息

Department of Medicine (Division of Cardiology), Einstein Institute for Aging Research, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York City, NY, USA.

Department of Molecular Pharmacology, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Einstein Institute for Neuroimmunology and Inflammation (INI), Fleischer Institute for Diabetes and Metabolism (FIDAM), Albert Einstein College of Medicine, New York City, NY, USA.

出版信息

Future Cardiol. 2025 Jan;21(1):5-8. doi: 10.1080/14796678.2024.2433381. Epub 2024 Nov 26.

DOI:10.1080/14796678.2024.2433381
PMID:39589856
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11812426/
Abstract
摘要

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The effects of Dapagliflozin in a real-world population of HFrEF patients with different hemodynamic profiles: worse is better.达格列净在不同血流动力学特征的射血分数降低心衰真实世界人群中的作用：越差越好。
Cardiovasc Diabetol. 2024 Nov 22;23(1):423. doi: 10.1186/s12933-024-02515-5.
2
SGLT2 inhibitors and GLP-1 receptor agonists: which is the best anti-frailty drug?钠-葡萄糖协同转运蛋白2抑制剂和胰高血糖素样肽-1受体激动剂：哪种是最佳抗衰弱药物？
Lancet Healthy Longev. 2024 Sep;5(9):100632. doi: 10.1016/j.lanhl.2024.08.001. Epub 2024 Sep 13.
3
Meta-analysis of sotagliflozin, a dual sodium-glucose-cotransporter 1/2 inhibitor, for heart failure in type 2 diabetes.钠-葡萄糖协同转运蛋白1/2双重抑制剂索格列净用于2型糖尿病心力衰竭的荟萃分析
ESC Heart Fail. 2025 Apr;12(2):968-979. doi: 10.1002/ehf2.15036. Epub 2024 Sep 10.
4
Semaglutide in Cardiometabolic Diseases: SELECTing the Target Population.司美格鲁肽在心脏代谢疾病中的应用：选择目标人群。
J Cardiovasc Dev Dis. 2024 May 7;11(5):145. doi: 10.3390/jcdd11050145.
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Editorial: Frailty and oxidative stress.社论：衰弱与氧化应激
Front Aging. 2024 Mar 6;4:1345486. doi: 10.3389/fragi.2023.1345486. eCollection 2023.
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GLP1 Receptor Agonists-Effects beyond Obesity and Diabetes.GLP1 受体激动剂——超越肥胖和糖尿病的作用。
Cells. 2023 Dec 28;13(1):65. doi: 10.3390/cells13010065.
7
Effects of SGLT2 inhibition via empagliflozin on cognitive and physical impairment in frail diabetic elders with chronic kidney disease.恩格列净抑制钠-葡萄糖协同转运蛋白2对老年体弱糖尿病肾病患者认知和身体功能损害的影响
Pharmacol Res. 2024 Feb;200:107055. doi: 10.1016/j.phrs.2023.107055. Epub 2024 Jan 2.
8
SGLT2 inhibitors: an evidence-based update on cardiovascular implications.钠-葡萄糖协同转运蛋白 2 抑制剂：心血管影响的循证更新。
Expert Opin Investig Drugs. 2023 Jul-Dec;32(9):839-847. doi: 10.1080/13543784.2023.2263354. Epub 2023 Oct 13.
9
Effect of sodium-glucose transporter 2 inhibitors on sarcopenia in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.钠-葡萄糖协同转运蛋白 2 抑制剂对 2 型糖尿病患者肌少症的影响：系统评价和荟萃分析。
Front Endocrinol (Lausanne). 2023 Jul 3;14:1203666. doi: 10.3389/fendo.2023.1203666. eCollection 2023.
10
Functional and Clinical Importance of SGLT2-inhibitors in Frailty: From the Kidney to the Heart.SGLT2 抑制剂在虚弱中的功能和临床重要性：从肾脏到心脏。
Hypertension. 2023 Sep;80(9):1800-1809. doi: 10.1161/HYPERTENSIONAHA.123.20598. Epub 2023 Jul 5.