Li Zhaoqi, Munim Muhammad Bin, Sharygin Daniel A, Bevis Brooke J, Vander Heiden Matthew G
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Cold Spring Harb Perspect Med. 2024 Sep 16. doi: 10.1101/cshperspect.a041532.
Rapidly proliferating cells, including cancer cells, adapt metabolism to meet the increased energetic and biosynthetic demands of cell growth and division. Many rapidly proliferating cells exhibit increased glucose consumption and fermentation regardless of oxygen availability, a phenotype termed aerobic glycolysis or the Warburg effect in cancer. Several explanations for why cells engage in aerobic glycolysis and how it supports proliferation have been proposed, but none can fully explain all conditions and data where aerobic glycolysis is observed. Nevertheless, there is convincing evidence that the Warburg effect is important for the proliferation of many cancers, and that inhibiting either glucose uptake or fermentation can impair tumor growth. Here, we discuss what is known about metabolism associated with aerobic glycolysis and the evidence supporting various explanations for why aerobic glycolysis may be important in cancer and other contexts.
包括癌细胞在内的快速增殖细胞会调整代谢，以满足细胞生长和分裂对能量及生物合成不断增加的需求。许多快速增殖细胞无论氧的可利用性如何，都表现出葡萄糖消耗和发酵增加，这种表型在癌症中被称为有氧糖酵解或瓦伯格效应。关于细胞进行有氧糖酵解的原因以及它如何支持增殖，已经提出了几种解释，但没有一种能够完全解释观察到有氧糖酵解的所有情况和数据。然而，有令人信服的证据表明，瓦伯格效应对于许多癌症的增殖很重要，并且抑制葡萄糖摄取或发酵会损害肿瘤生长。在这里，我们讨论与有氧糖酵解相关的代谢知识，以及支持有氧糖酵解在癌症和其他情况下可能重要的各种解释的证据。
