Lysell L, Rohlin M
Int J Oral Surg. 1985 Aug;14(4):371-5. doi: 10.1016/s0300-9785(85)80027-2.
Radionuclide imaging has been suggested as a means to assess healing and viability of bone grafts and implants. This study deals with the in vivo uptake of 99mTc-MDP in the initial postoperative period in rats. Isogeneic or xenogeneic bone was implanted in subcutaneous pouches. The isogeneic grafts and implants were treated with saline or freeze-treated or demineralized. The xenogeneic implants consisted of Kiel bone or collagen sponge. One day after surgery, the accumulation of 99mTc after an intraperitoneal injection of 99mTc-MDP was seen in all grafts and implants containing bone mineral independent of prior treatment of the graft and implant. In implants composed of only the organic part of bone, no accumulation was observed. One prerequisite for accumulation of 99mTc-MDP is the presence of the inorganic phase. Thus, the interpretation of the initial postoperative scan is based on whether or not the graft or implant initially contained mineral.
放射性核素成像已被提议作为评估骨移植和植入物愈合及存活情况的一种手段。本研究探讨了大鼠术后初期99mTc-MDP的体内摄取情况。将同基因或异种骨植入皮下袋中。同基因移植物和植入物用生理盐水处理、冷冻处理或脱矿处理。异种植入物由基尔骨或胶原海绵组成。术后一天，在所有含有骨矿物质的移植物和植入物中，腹腔注射99mTc-MDP后均可见99mTc的积聚，与移植物和植入物先前的处理无关。在仅由骨有机部分组成的植入物中，未观察到积聚。99mTc-MDP积聚的一个前提条件是无机相的存在。因此，术后初期扫描的解读基于移植物或植入物最初是否含有矿物质。
