Lipson R A, Dief H, Greyson N D, Kawano H, Gross A E, Langer F, Halloran P F
Clin Orthop Relat Res. 1981 Oct(160):279-89.
One hundred and eight bone scans using 99mTechnetium methylene diphosphonate (MDP) were performed in rats undergoing vascularized and nonvascularized syngeneic and allogeneic transplants of the hind limb, and in control animals. A six-level system of grading the radionuclide uptake in the graft was used to evaluate healing or complications of the transplantation. Bone scanning was superior to other modalities in assessing viability of the graft. Bone scans were able to: (1) immediately confirm vascular patency, thus obviating angiography; (2) demonstrate differences in the rate of repair in syngeneic and allogeneic nonvascularized grafts; (3) sequentially assess vascularized allograft rejection; and (4) document long-term effects, such as bone atrophy due to disuse and early epiphyseal maturity.
使用99m锝亚甲基二膦酸盐（MDP）对接受后肢血管化和非血管化同基因及异基因移植的大鼠以及对照动物进行了108次骨扫描。采用六级系统对移植物中的放射性核素摄取进行分级，以评估移植的愈合情况或并发症。在评估移植物的存活能力方面，骨扫描优于其他检查方式。骨扫描能够：（1）立即确认血管通畅，从而无需进行血管造影；（2）显示同基因和异基因非血管化移植物修复速度的差异；（3）连续评估血管化同种异体移植物的排斥反应；（4）记录长期影响，如废用性骨萎缩和早期骨骺成熟。
