McPhee Patrick G, Ball Geoff D C, Buchholz Annick, Hamilton Jill K, Ho Josephine, Zenlea Ian, Thabane Lehana, Morrison Katherine M
Department of Pediatrics, McMaster University, Hamilton, ON, Canada.
Centre for Metabolism, Obesity, and Diabetes Research, McMaster University, Hamilton, ON, Canada.
Int J Obes (Lond). 2025 Jan;49(1):109-117. doi: 10.1038/s41366-024-01631-2. Epub 2024 Sep 16.
To examine individual, family, and program characteristics associated with changes in anthropometric and cardiometabolic health indicators in children with overweight or obesity after participating in multidisciplinary obesity management for 12 months.
Participants included children 2-17 years old with overweight or obesity enrolled in the CANadian Pediatric Weight Management Registry (CANPWR). Multiple linear regression analyses were conducted to investigate the associations between individual, family, and program characteristics and changes in anthropometry (WHO BMI z-score) and cardiometabolic health indicators (systolic and diastolic blood pressure; fasting and 2-h glucose post-oral glucose tolerance test (OGTT); high density lipoprotein- (HDL) and non-HDL cholesterol and fasting triglycerides).
BMI z-score data were available from 1065/1286 (82.8%) at 6-months post-baseline and 893/1286 (69.4%) at 12-months post-baseline. At 6-months, BMI z-score decreased relative to baseline (mean difference (MD) [95% confidence interval (CI)] = -0.08 [-0.10 to -0.06]; p < 0.001). BMI z-score (MD [95% CI] = -0.08 [-0.13 to -0.04); p = 0.001) and fasting triglycerides (MD [95% CI] = -0.07 [-0.13 to -0.02); p = 0.011) decreased at 12 months from baseline. Older age at baseline (estimated β = 0.025; 95% CI [0.006, 0.042], p = 0.007) and female sex (estimated β = 0.241; 95% CI [0.108, 0.329], p < 0.001) were associated with a worsened Δ BMI z-score at 12 months, while total hours with mental health provider (estimated β = -0.015; 95% CI [-0.030, -0.001], p = 0.049) was associated with an improved Δ BMI z-score at 12 months. Hours with an exercise counselor (estimated β = 0.023; 95% CI [0.008, 0.039], p = 0.003) were associated with improved HDL, while hours with a registered dietitian (estimated β = -0.026; 95% CI [-0.051, -0.001], p = 0.044) were associated with improved non-HDL cholesterol.
Male sex and hours spent with a mental health provider, exercise counselor, and registered dietitian were related to significant improvements in several anthropometric and cardiometabolic health indicators at 12 months post-baseline.
研究超重或肥胖儿童在参与为期12个月的多学科肥胖管理后,其人体测量指标和心脏代谢健康指标变化所相关的个体、家庭及项目特征。
参与者包括纳入加拿大儿童体重管理登记系统(CANPWR)的2至17岁超重或肥胖儿童。进行多元线性回归分析,以研究个体、家庭及项目特征与人体测量指标(世界卫生组织BMI z评分)和心脏代谢健康指标(收缩压和舒张压;口服葡萄糖耐量试验(OGTT)后的空腹及2小时血糖;高密度脂蛋白(HDL)和非HDL胆固醇以及空腹甘油三酯)变化之间的关联。
基线后6个月时,1065/1286(82.8%)的儿童有BMI z评分数据;基线后12个月时,893/1286(69.4%)的儿童有该数据。在6个月时,BMI z评分相对于基线下降(平均差值(MD)[95%置信区间(CI)]= -0.08[-0.10至-0.06];p<0.001)。在12个月时,BMI z评分(MD[95%CI]= -0.08[-0.13至-0.04];p = 0.001)和空腹甘油三酯(MD[95%CI]= -0.07[-0.13至-0.02];p = 0.011)相对于基线下降。基线时年龄较大(估计β= 0.025;95%CI[0.006, 0.042],p = 0.007)和女性(估计β= 0.241;95%CI[0.108, 0.329],p<0.001)与12个月时BMI z评分变化恶化相关,而与心理健康服务提供者接触的总时长(估计β= -0.015;95%CI[-0.030, -0.001],p = 0.049)与12个月时BMI z评分变化改善相关。与运动顾问接触的时长(估计β= 0.023;95%CI[0.008, 0.039],p = 0.003)与HDL改善相关,而与注册营养师接触的时长(估计β= -0.026;95%CI[-0.051, -0.001],p = 0.044)与非HDL胆固醇改善相关。
男性以及与心理健康服务提供者、运动顾问和注册营养师接触的时长,与基线后12个月时多项人体测量指标和心脏代谢健康指标的显著改善有关。