Wilasrusmee Kittikorn Tommy, Sitticharoon Chantacha, Keadkraichaiwat Issarawan, Maikaew Pailin, Pongwattanapakin Kitchaya, Chatree Saimai, Sririwichitchai Rungnapa, Churintaraphan Malika
Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Rd., Siriraj, Bangkoknoi, Bangkok, 10700, Thailand.
Sci Rep. 2024 Sep 16;14(1):21628. doi: 10.1038/s41598-024-72269-3.
This study aimed to investigate effects of epigallocatechin gallate (EGCG) on blood pressure (BP) and autonomic nervous system, indicated by 5-min heart rate variability (HRV) measurement in obese subjects, and determine correlations of BP with metabolic factors. In a double-blind, randomized controlled trial, obese subjects (n = 30) were randomly allocated to receive 150 mg EGCG (n = 15) or placebo (n = 15) twice a day without dietary restrictions. After 8-week EGCG treatment, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) significantly decreased, while the low-frequency (LF) to high-frequency power (HF) ratio (LF/HF ratio) significantly increased (P < 0.05 all), indicating a shift toward sympathetic dominance, either directly or indirectly after BP lowering. SBP had positive correlations with obesity parameters, leptin, insulin, and insulin resistance but had a negative correlation with insulin sensitivity. DBP was positively correlated with age and HF in normalized unit, but negatively correlated with height and LF in ms. High-density lipoprotein cholesterol (HDL-C) was negatively correlated with SBP, DBP, and MAP reflecting its protective effect against elevated BP. In conclusion, the 8-week EGCG treatment decreased BP and increased the LF/HF ratio, reflecting increased sympathetic activity, either a direct EGCG effect or an indirect compensatory response following BP reduction.
本研究旨在通过测量肥胖受试者5分钟心率变异性（HRV）来探究表没食子儿没食子酸酯（EGCG）对血压（BP）和自主神经系统的影响，并确定血压与代谢因子之间的相关性。在一项双盲随机对照试验中，肥胖受试者（n = 30）被随机分为两组，一组每天两次服用150毫克EGCG（n = 15），另一组每天两次服用安慰剂（n = 15），饮食不限。经过8周的EGCG治疗后，收缩压（SBP）、舒张压（DBP）和平均动脉压（MAP）显著降低，而低频（LF）与高频功率（HF）比值（LF/HF比值）显著升高（均P < 0.05），这表明在血压降低后，直接或间接出现了向交感神经优势的转变。SBP与肥胖参数、瘦素、胰岛素及胰岛素抵抗呈正相关，但与胰岛素敏感性呈负相关。DBP与年龄及标准化单位下的HF呈正相关，但与身高及毫秒单位下的LF呈负相关。高密度脂蛋白胆固醇（HDL-C）与SBP、DBP和MAP呈负相关，反映出其对血压升高的保护作用。总之，8周的EGCG治疗降低了血压并提高了LF/HF比值，这反映出交感神经活动增强，这可能是EGCG的直接作用，也可能是血压降低后的间接代偿反应。
