Fricke Tabea C, Leffler Andreas
Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Carl-Neuberg Strasse 1, 30625, Hannover, Germany.
J Physiol Sci. 2024 Sep 16;74(1):42. doi: 10.1186/s12576-024-00936-1.
Transient receptor potential (TRP) ion channels serve as sensors for variations in ambient temperature, modulating both thermoregulation and temperature responsive cellular processes. Among these, the vanilloid TRP subfamily (TRPV) comprises six members and at least four of these members (TRPV1-TRPV4) have been associated with thermal sensation. TRPV2 has been described as a sensor for noxious heat, but subsequent studies have unveiled a more complex role for TRPV2 beyond temperature perception. This comprehensive review aims to elucidate the intricate thermosensitivity of TRPV2 by synthesizing current knowledge on its biophysical properties, expression pattern and known physiological functions associated with thermosensation.
瞬时受体电位（TRP）离子通道作为环境温度变化的传感器，调节体温调节和温度响应性细胞过程。其中，香草酸TRP亚家族（TRPV）包含六个成员，其中至少四个成员（TRPV1 - TRPV4）与热感觉有关。TRPV2已被描述为有害热的传感器，但随后的研究揭示了TRPV2在温度感知之外更复杂的作用。这篇综述旨在通过综合目前关于TRPV2的生物物理特性、表达模式和与热感觉相关的已知生理功能的知识，阐明其复杂的热敏性。
