Takagaki Masatoshi, Kawabata Shuhei, Kishima Haruhiko
Department of Neurosurgery, Osaka University Graduate School of Medicine.
No Shinkei Geka. 2024 Sep;52(5):931-937. doi: 10.11477/mf.1436205002.
In recent years, the association of the microbiome with various diseases has been reported. The oral and gut microbiomes have been linked to cerebral aneurysms and are involved in the systemic inflammatory response, which is mediated mainly via the immune system. Chronic inflammation plays an important role in the pathogenesis and rupture of cerebral aneurysms, and the microbiome is potentially involved in this process. Moreover, the gut microbiome is involved in acute brain injury following subarachnoid hemorrhage. Thus, further studies on microbiome-targeted treatments for cerebral aneurysm are required.
近年来，已有报道称微生物群与多种疾病有关联。口腔和肠道微生物群已被证实与脑动脉瘤有关，并参与全身炎症反应，这一反应主要通过免疫系统介导。慢性炎症在脑动脉瘤的发病机制和破裂过程中起重要作用，微生物群可能参与了这一过程。此外，肠道微生物群还与蛛网膜下腔出血后的急性脑损伤有关。因此，需要进一步开展针对微生物群的脑动脉瘤治疗研究。
