Kubo K, Ishikura T, Fukagawa Y
J Antibiot (Tokyo). 1985 Jul;38(7):904-11. doi: 10.7164/antibiotics.38.904.
Radioactive beta-alanine was specifically incorporated into the beta-alanine moiety of the C-3 pantetheinyl side chain of the OA-6129 group of carbapenems by Streptomyces sp. OA-6129, while no added radioactive pantothenate was taken up into the mycelia. The extracellular concentrations of beta-alanine and pantothenate in the broth of Streptomyces sp. OA-6129 increased with the production of the carbapenems. The production levels of beta-alanine and pantothenate markedly differed between carbapenem-producing streptomycetes and nonproducers, with the exception of Streptomyces cattleya, a thienamycin producer, suggesting a possible relation of carbapenem biosynthesis with the levels of beta-alanine and pantothenate.
链霉菌属OA-6129可将放射性β-丙氨酸特异性掺入碳青霉烯类OA-6129组C-3泛酰巯基乙胺侧链的β-丙氨酸部分，而未添加的放射性泛酸盐未被菌丝体摄取。链霉菌属OA-6129发酵液中β-丙氨酸和泛酸盐的细胞外浓度随碳青霉烯类的产生而增加。除了噻烯霉素产生菌卡特利链霉菌外，产生碳青霉烯类的链霉菌和不产生碳青霉烯类的链霉菌之间β-丙氨酸和泛酸盐的产生水平有显著差异，这表明碳青霉烯类生物合成可能与β-丙氨酸和泛酸盐的水平有关。
