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Mutation of Pseudomonas aeruginosa to piperacillin resistance mediated by beta-lactamase production.

作者信息

Bell S M, Pham J N, Lanzarone J Y

出版信息

J Antimicrob Chemother. 1985 Jun;15(6):665-70. doi: 10.1093/jac/15.6.665.

DOI:10.1093/jac/15.6.665
PMID:3928573
Abstract

Piperacillin-resistant mutants were detected in each of ten strains of Pseudomonas aeruginosa. The resistance was associated with constitutive production by the strains of high levels of beta-lactamase which was similar in character to the induced chromosomal Id beta-lactamase of the parent strains. This type of mutation to piperacillin-resistance occurred at a low frequency. The beta-lactamase production and piperacillin-resistance were stable on repeated subculture and prolonged storage of the strains.

摘要

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