铜绿假单胞菌染色体β-内酰胺酶调控改变的突变体对哌拉西林、头孢他啶和头孢磺啶的耐药性。
Resistance of Pseudomonas aeruginosa mutants with altered control of chromosomal beta-lactamase to piperacillin, ceftazidime, and cefsulodin.
作者信息
Bryan L E, Kwan S, Godfrey A J
出版信息
Antimicrob Agents Chemother. 1984 Mar;25(3):382-4. doi: 10.1128/AAC.25.3.382.
Abstract
Examination of beta-lactam susceptibility of mutants altered in the control of chromosomal beta-lactamase of Pseudomonas aeruginosa supports the view that a constitutive level of beta-lactamase is not an adequate explanation for resistance to cefsulodin and ceftazidime but could be for resistance to piperacillin which has an efficiency of hydrolysis ca. 10 times higher than does cefsulodin or ceftazidime.
摘要
对铜绿假单胞菌染色体β-内酰胺酶调控发生改变的突变体进行β-内酰胺敏感性检测，支持以下观点：β-内酰胺酶的组成型水平并不能充分解释对头孢磺啶和头孢他啶的耐药性，但可能是对哌拉西林耐药的原因，哌拉西林的水解效率比头孢磺啶或头孢他啶高约10倍。
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