在前列腺、肺、结肠直肠癌、卵巢癌筛查试验中矿物质摄入量与结直肠癌风险的关联。
Associations of minerals intake with colorectal cancer risk in the prostate, lung, colorectal, ovarian cancer screening trial.
作者信息
Li Siyue, Ren Qingqian, Song Zixuan, Liu Baixue, Wang Dan, Shang Yanna, Wang Hao
机构信息
Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
出版信息
Front Nutr. 2024 Sep 2;11:1445369. doi: 10.3389/fnut.2024.1445369. eCollection 2024.
OBJECTIVE
Exploring the association between common mineral intake and the risk of colorectal cancer (CRC).
METHODS
We utilized the multivariate Cox proportional hazards model to assess the association between intake of minerals and the risk of CRC, estimating hazard ratios (HRs) and 95% confidence intervals (CIs).
RESULTS
A total of 101,686 eligible participants were included in the analysis of this study, including 1,100 CRC cases. After adjusting for potential confounders, we found that total zinc intake (HR: 0.79, 95%CI 0.67-0.93; for trend <0.05), iron intake (HR: 0.81, 95%CI 0.68-0.96; for trend <0.05), copper intake (HR: 0.80, 95%CI 0.68-0.95; for trend <0.05), selenium intake (HR: 0.83, 95%CI 0.69-0.98; for trend <0.05) were significantly negatively associated with the incidence of CRC, but magnesium intake in the appropriate range is associated with a reduced risk of CRC (HR: 0.77, 95%CI 0.65-0.91; for trend >0.05).
CONCLUSION
Our findings suggested that an appropriate intake of total zinc, iron, copper, selenium and magnesium were associated with lower CRC risk.
目的
探讨常见矿物质摄入量与结直肠癌（CRC）风险之间的关联。
方法
我们使用多变量Cox比例风险模型评估矿物质摄入量与CRC风险之间的关联，估计风险比（HRs）和95%置信区间（CIs）。
结果
本研究分析共纳入101,686名符合条件的参与者，包括1,100例CRC病例。在调整潜在混杂因素后，我们发现总锌摄入量（HR：0.79，95%CI 0.67 - 0.93；趋势<0.05）、铁摄入量（HR：0.81，95%CI 0.68 - 0.96；趋势<0.05）、铜摄入量（HR：0.80，95%CI 0.68 - 0.95；趋势<0.05）、硒摄入量（HR：0.83，95%CI 0.69 - 0.98；趋势<0.05）与CRC发病率显著负相关，但适当范围内的镁摄入量与CRC风险降低相关（HR：0.77，95%CI 0.65 - 0.91；趋势>0.05）。
结论
我们的研究结果表明，适当摄入总锌、铁、铜、硒和镁与较低的CRC风险相关。
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