Department of Nutrition, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, 450000, Henan, China.
Sci Rep. 2023 Sep 26;13(1):16103. doi: 10.1038/s41598-023-43481-4.
Previous studies on the relationship between dietary minerals and preeclampsia (PE) have given inconsistent results. The aim of this study was to further clarify the relationship between dietary minerals intake and PE in Chinese pregnant women. In this study, 440 pairs of hospital-based preeclamptic and healthy women were matched 1:1. Dietary intake was obtained through a 78-item semi-quantitative food frequency questionnaire. Multivariate conditional logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were plotted to evaluate the dose-response relationship between dietary minerals intake and PE. This study found significant inverse associations for dietary intake of calcium, magnesium, phosphorus, iron, copper, manganese and zinc and the risk of PE in both univariate and multivariate models (all P- trend < 0.05). After adjusting for possible confounders, compared with the lowest quartile, the odds ratio of the highest quartile was 0.74 (95% CI 0.56-0.98) for calcium, 0.63 (95% CI 0.42-0.93) for magnesium, 0.45 (95% CI 0.31-0.65) for phosphorus, 0.44 (95% CI 0.30-0.65) for iron, 0.72 (95% CI 0.53-0.97) for copper, 0.66 (95% CI 0.48-0.91) for manganese and 0.38 (95% CI 0.25-0.57) for zinc. In addition, a reverse J-shaped relationship between dietary minerals intake and PE risk was observed (P-overall association < 0.05). In Chinese pregnant women, a higher intake of dietary minerals, including calcium, magnesium, phosphorus, copper, iron, manganese, and zinc was associated with a lower odds of PE.
先前关于膳食矿物质与子痫前期（PE）之间关系的研究结果并不一致。本研究旨在进一步阐明中国孕妇膳食矿物质摄入与 PE 之间的关系。在这项研究中，以 1:1 的比例匹配了 440 对基于医院的子痫前期和健康孕妇。通过 78 项半定量食物频率问卷获得膳食摄入量。使用多变量条件逻辑回归来估计比值比（OR）和 95％置信区间（CI）。受限立方样条用于评估膳食矿物质摄入与 PE 之间的剂量反应关系。本研究在单变量和多变量模型中均发现膳食钙、镁、磷、铁、铜、锰和锌的摄入量与 PE 风险呈显著负相关（均 P-趋势 < 0.05）。在校正可能的混杂因素后，与最低四分位相比，最高四分位的钙、镁、磷、铁、铜、锰和锌的比值比分别为 0.74（95％CI 0.56-0.98）、0.63（95％CI 0.42-0.93）、0.45（95％CI 0.31-0.65）、0.44（95％CI 0.30-0.65）、0.72（95％CI 0.53-0.97）、0.66（95％CI 0.48-0.91）和 0.38（95％CI 0.25-0.57）。此外，还观察到膳食矿物质摄入与 PE 风险之间存在反向 J 形关系（P 总体关联 < 0.05）。在中国孕妇中，较高的膳食矿物质摄入，包括钙、镁、磷、铜、铁、锰和锌，与较低的 PE 发生几率相关。
