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子宫脂肪平滑肌肉瘤伴多形性脂肪肉瘤:CT表现与病理对照。1例病例报告并文献复习。

Lipoleiomyosarcoma with pleomorphic liposarcoma of the uterus: Computed tomography findings with pathological correlation. A case report and review of literature.

作者信息

Arpaia Valerio, Pirolo Luigi, Sfregola Stefania, Licata Luana, Iovino Maria, Sanduzzi Luca, Ferrante Anna, Varriale Elisa, Iacobelli Pietro, Sandomenico Fabio

机构信息

Diagnostic Imaging and Radiotherapy Department, University "Federico II", Naples 80131, Italy.

Radiology Department, Buon Consiglio Fatebenefratelli Hospital, Naples 80123, Italy.

出版信息

Radiol Case Rep. 2024 Sep 3;19(11):5474-5480. doi: 10.1016/j.radcr.2024.08.004. eCollection 2024 Nov.

DOI:10.1016/j.radcr.2024.08.004
PMID:39285970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11403635/
Abstract

Uterine lipoleiomyosarcomas (L-LMS) are rare malignant tumors with only few cases descripted in literature. As well, liposarcomas (LPS) arising from uterine corpus are extremely rare since fat tissue is commonly poor or absent in uterus. We report a case of L-LMS of the uterine corpus with an associated component of pleomorphic LPS. As for other female pelvic malignancies, these neoplasms are more common in postmenopausal women and clinical findings are nonspecific. Most frequent signs and symptoms are metrorrhagia and abdominal pain often associated with pelvic distension/mass. We describe diagnostic and therapeutic steps of our patient from acceptation to conclusive diagnosis. In this case, contrast-enhanced computed tomography (CECT) depicted pivotal diagnostic findings and showed a clear distinction between different tumor components. Therefore, our goal with this essay is to stress the role of CECT imaging for diagnosis of these rare neoplasms. We also perform a review of current literature about liposarcomas of the uterine corpus.

摘要

子宫脂肪平滑肌肉瘤(L-LMS)是罕见的恶性肿瘤,文献中仅有少数病例描述。同样,子宫体部发生的脂肪肉瘤(LPS)极为罕见,因为子宫中通常缺乏脂肪组织或脂肪组织很少。我们报告一例子宫体部L-LMS病例,伴有多形性LPS成分。与其他女性盆腔恶性肿瘤一样,这些肿瘤在绝经后女性中更为常见,临床表现无特异性。最常见的体征和症状是子宫出血和腹痛,常伴有盆腔扩张/肿块。我们描述了该患者从入院到最终确诊的诊断和治疗步骤。在本病例中,对比增强计算机断层扫描(CECT)显示了关键的诊断结果,并清晰区分了不同的肿瘤成分。因此,我们撰写本文的目的是强调CECT成像在诊断这些罕见肿瘤中的作用。我们还对目前关于子宫体部脂肪肉瘤的文献进行了综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e4d/11403635/0e4f8a3ccbb1/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e4d/11403635/7319737b80e6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e4d/11403635/ccf74aef813c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e4d/11403635/d69fb507f376/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e4d/11403635/0e4f8a3ccbb1/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e4d/11403635/7319737b80e6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e4d/11403635/ccf74aef813c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e4d/11403635/d69fb507f376/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e4d/11403635/0e4f8a3ccbb1/gr4.jpg

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Uterine sarcomas: clinical practice guidelines for diagnosis, treatment, and follow-up, by Spanish group for research on sarcomas (GEIS).子宫肉瘤:西班牙肉瘤研究小组(GEIS)制定的诊断、治疗及随访临床实践指南
Ther Adv Med Oncol. 2023 Mar 28;15:17588359231157645. doi: 10.1177/17588359231157645. eCollection 2023.
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MRI Evaluation of Uterine Masses for Risk of Leiomyosarcoma: A Consensus Statement.
MRI 评估子宫肿块发生平滑肌肉瘤的风险:共识声明。
Radiology. 2023 Feb;306(2):e211658. doi: 10.1148/radiol.211658. Epub 2022 Oct 4.
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A Novel Tool to Predict Early Death in Uterine Sarcoma Patients: A Surveillance, Epidemiology, and End Results-Based Study.一种预测子宫肉瘤患者早期死亡的新型工具:一项基于监测、流行病学和最终结果的研究。
Front Oncol. 2020 Nov 26;10:608548. doi: 10.3389/fonc.2020.608548. eCollection 2020.
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