Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan.
Int J Gynecol Pathol. 2012 Jul;31(4):358-63. doi: 10.1097/PGP.0b013e31823f841f.
Uterine lipoleiomyosarcoma is a rare entity with only 6 case reports in the Pubmed database at the time of writing this article. We report 2 additional cases of uterine lipoleiomyosarcoma, characterized on microscopy by coexistence of leiomyosarcomatous and liposarcomatous components, with focal intermingling, without an intervening lipoleiomyomatous area. The liposarcomatous component in both of our cases had the morphology of myxoid liposarcoma. Both cases underwent postoperative chemotherapy. One of our cases had recurrence in the pelvis with microscopic features of myxoid liposarcoma. This patient died with multiple metastases 4.5 yr after hysterectomy, with the metastatic lesions being liposarcomas, without an evident leiomyosarcomatous component. Although lacking a treatment protocol because of the rarity of such cases, postoperative adjuvant therapy is mandatory.
子宫脂肪平滑肌肉瘤是一种罕见的实体瘤，在撰写本文时，PubMed 数据库中仅有 6 例病例报告。我们报告了另外 2 例子宫脂肪平滑肌肉瘤病例，显微镜下表现为平滑肌肉瘤和脂肪肉瘤成分共存，局灶性混合，无中间性脂肪平滑肌瘤区域。我们的 2 例脂肪肉瘤成分均具有黏液样脂肪肉瘤的形态。这 2 例病例均接受了术后化疗。我们的 1 例病例在盆腔复发，具有黏液样脂肪肉瘤的微观特征。该患者在子宫切除术后 4.5 年死于多发性转移，转移病灶为脂肪肉瘤，无明显平滑肌肉瘤成分。尽管由于这种病例罕见而缺乏治疗方案，但术后辅助治疗是必需的。
