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原始单价和二价新冠疫苗对未免疫功能低下的孕妇新冠相关急诊科和紧急护理就诊的有效性：VISION网络，2022年6月至2023年8月

Effectiveness of the Original Monovalent and Bivalent COVID-19 Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters in Pregnant Persons Who Were Not Immunocompromised: VISION Network, June 2022-August 2023.

作者信息

Avrich Ciesla Allison, Lazariu Victoria, Dascomb Kristin, Irving Stephanie A, Dixon Brian E, Gaglani Manjusha, Naleway Allison L, Grannis Shaun J, Ball Sarah, Kharbanda Anupam B, Vazquez-Benitez Gabriela, Klein Nicola P, Natarajan Karthik, Ong Toan C, Embi Peter J, Fleming-Dutra Katherine E, Link-Gelles Ruth, Zerbo Ousseny

机构信息

Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Eagle Health Analytics, San Antonio, Texas, USA.

出版信息

Open Forum Infect Dis. 2024 Aug 28;11(9):ofae481. doi: 10.1093/ofid/ofae481. eCollection 2024 Sep.

DOI:10.1093/ofid/ofae481
PMID:39286032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11403472/
Abstract

Pregnant people face increased risk of severe COVID-19. Current guidelines recommend updated COVID-19 vaccination (2023-2024) for those aged ≥6 months, irrespective of pregnancy status. To refine recommendations for pregnant people, further data are needed. Using a test-negative design, we evaluated COVID-19 vaccine effectiveness against medically attended COVID-19 with COVID-19-like illness among pregnant people aged 18 to 45 years during June 2022 to August 2023. When doses were received during pregnancy, vaccine effectiveness was 52% (95% CI, 29%-67%); when received <6 months prior to pregnancy, 28% (95% CI, 11%-42%); and when received ≥6 months prior to pregnancy, 6% (95% CI, -11% to 21%). Pregnant people should stay up-to-date with recommended COVID-19 vaccination.

摘要

孕妇面临患重症 COVID-19 的风险增加。当前指南建议为年龄≥6 个月的人群接种更新的 COVID-19 疫苗（2023 - 2024 年），无论其妊娠状态如何。为完善针对孕妇的建议，还需要更多数据。我们采用检测阴性设计，评估了 2022 年 6 月至 2023 年 8 月期间 18 至 45 岁孕妇中 COVID-19 疫苗对因 COVID-19 样疾病就医的 COVID-19 的有效性。孕期接种疫苗时，疫苗有效性为 52%（95%置信区间，29% - 67%）；孕前<6 个月接种时，为 28%（95%置信区间，11% - 42%）；孕前≥6 个月接种时，为 6%（95%置信区间，-11%至 21%）。孕妇应及时接种推荐的 COVID-19 疫苗。

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