一种用于肺血栓栓塞症诊断和预后评估的新型生物标志物：血清原肌球蛋白-1

A new biomarker in the diagnosis and prognosis of pulmonary thromboembolism: Serum profilin-1.

作者信息

Erdem Elif, Yadigaroğlu Metin, Güzel Murat, Gülbüz Levent, Yılman Metehan, Ocak Metin, Arslan Aksu Esra, Görgün Selim, Yücel Murat

机构信息

Şehit Aydoğan Aydın State Hospital, Emergency Clinic, Şırnak, Turkey.

Samsun University, Faculty of Medicine, Department of Emergency Medicine, Samsun, Turkey.

出版信息

Heliyon. 2024 Aug 28;10(17):e37102. doi: 10.1016/j.heliyon.2024.e37102. eCollection 2024 Sep 15.

DOI:10.1016/j.heliyon.2024.e37102

PMID:39286213

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11403089/

Abstract

OBJECTIVE

Pulmonary Thromboembolism (PTE) is one of the major cardiovascular diseases with high morbidity and mortality. Early diagnosis and accurate prognosis are essential in clinical management. This study aimed to investigate the efficacy of serum Profilin-1(PFN1) in diagnosing and prognosis PTE.

MATERIALS AND METHODS

This study was conducted on patients older than 18 diagnosed with PTE and healthy volunteers with similar sociodemographic characteristics who applied to the emergency department between March 2022 and March 2023.

RESULTS

In the study, 102 patients diagnosed with PTE were in the patient group, and 64 healthy volunteers were in the control group. The median PFN1 level of the patient group was 2878 (124-5001) pg/mL, while the median PFN1 level of the control group was 579 (125-5001) pg/mL. The PFN1 level of the patient group was significantly higher than the control group (p < 0.001). PFN1 levels of 984.46 pg/mL and above had 76.47 % sensitivity and 79.69 % specificity in diagnosing PTE (AUC: 0.817; CI: 0.750-0.873; p < 0.0001). The median PFN1 level of patients with mortality was 5001 (1793.3-5001) pg/mL, while the median PFN1 level of patients without mortality was 1858 (124-5001) pg/mL. PFN1 levels of patients who developed mortality were significantly higher than those who did not develop mortality (p < 0.001). PFN1 levels of 3292.1 pg/mL and above had 90.91 % sensitivity and 71.25 % specificity in PTE prognosis (AUC: 0.861; CI: 0.778-0.921; p < 0.0001).

CONCLUSION

Serum Profilin-1 levels are helpful as a diagnostic and prognostic indicator in PTE.

摘要

目的

肺血栓栓塞症（PTE）是主要的心血管疾病之一，发病率和死亡率高。早期诊断和准确的预后在临床管理中至关重要。本研究旨在探讨血清丝切蛋白-1（PFN1）在PTE诊断和预后中的作用。

材料与方法

本研究对2022年3月至2023年3月期间到急诊科就诊的18岁以上确诊为PTE的患者以及具有相似社会人口学特征的健康志愿者进行。

结果

研究中，患者组有102例确诊为PTE的患者，对照组有64名健康志愿者。患者组PFN1水平中位数为2878（124 - 5001）pg/mL，而对照组PFN1水平中位数为579（125 - 5001）pg/mL。患者组PFN1水平显著高于对照组（p < 0.001）。PFN1水平在984.46 pg/mL及以上时，诊断PTE的灵敏度为76.47%，特异度为79.69%（AUC：0.817；CI：0.750 - 0.873；p < 0.0001）。死亡患者的PFN1水平中位数为5001（1793.3 - 5001）pg/mL，未死亡患者的PFN1水平中位数为1858（124 - 5001）pg/mL。发生死亡的患者PFN1水平显著高于未发生死亡的患者（p < 0.001）。PFN1水平在3292.1 pg/mL及以上时，PTE预后的灵敏度为90.91%，特异度为71.25%（AUC：0.861；CI：0.778 - 0.921；p < 0.0001）。