一种具有抗氧化活性的生物功能冷冻凝胶，有望应用于骨组织修复。
A bio-functional cryogel with antioxidant activity for potential application in bone tissue repairing.
作者信息
Chen Feng, Zheng Wenbiao, Yang Zeyu, Wang Wei, Huang Jiehe
机构信息
Department of Orthopedics, Taizhou Municipal Hospital, Taizhou, 318000, Zhejiang Province, PR China.
Department of Tumor Intervention, Taizhou Municipal Hospital, Taizhou, 318000, Zhejiang Province, PR China.
出版信息
Heliyon. 2024 Aug 28;10(17):e37055. doi: 10.1016/j.heliyon.2024.e37055. eCollection 2024 Sep 15.
Antioxidant and free radical resistance has been a key concern of tissue engineering. In this study, Hydroxyapatite (HAp) with osteogenic activity and Oligomeric Proantho Cyanidins (OPC) with antioxidant activity were chemically grafted to prepare gelatin-based biofunctional aerogel (GHPOS). SEM results confirmed that these aerogels exhibited obvious macroporous structure and could provide a suitable microenvironment for bone cell growth. The addition of HAP-PEI-OPC made it have good antioxidant activity, and the cell results proved that the aerogel prepared in this study had good cytocompatibility and did not produce cytotoxicity. The addition of nanoparticles played an important role in the activity of 3T3-E1. The results showed that these bioactive aerogel scaffolds have potential applications in bone tissue engineering.
抗氧化和自由基抗性一直是组织工程的关键关注点。在本研究中，将具有成骨活性的羟基磷灰石（HAp）和具有抗氧化活性的低聚原花青素（OPC）进行化学接枝，以制备基于明胶的生物功能气凝胶（GHPOS）。扫描电子显微镜（SEM）结果证实，这些气凝胶呈现出明显的大孔结构，可为骨细胞生长提供适宜的微环境。HAP-PEI-OPC的添加使其具有良好的抗氧化活性，细胞实验结果证明本研究制备的气凝胶具有良好的细胞相容性且不产生细胞毒性。纳米颗粒的添加对3T3-E1的活性起到重要作用。结果表明，这些生物活性气凝胶支架在骨组织工程中具有潜在应用。
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