阿尔茨海默病预后中的T淋巴细胞比例。
T lymphocyte proportion in Alzheimer's disease prognosis.
作者信息
Willman Matthew, Patel Gopi, Lucke-Wold Brandon
机构信息
College of Medicine, University of Florida, Gainesville, FL 32610, United States.
Department of Neurosurgery, University of Florida, Gainesville, FL 32611, United States.
出版信息
World J Clin Cases. 2024 Sep 16;12(26):6001-6003. doi: 10.12998/wjcc.v12.i26.6001.
Bai investigate the predictive value of T lymphocyte proportion in Alzheimer's disease (AD) prognosis. Through a retrospective study involving 62 AD patients, they found that a decrease in T lymphocyte proportion correlated with a poorer prognosis, as indicated by higher modified Rankin scale scores. While the study highlights the potential of T lymphocyte proportion as a prognostic marker, it suggests the need for larger, multicenter studies to enhance generalizability and validity. Additionally, future research could use cognitive exams when evaluating prognosis and delve into immune mechanisms underlying AD progression. Despite limitations inherent in retrospective designs, Bai 's work contributes to understanding the immune system's role in AD prognosis, paving the way for further exploration in this under-researched area.
白（等人）研究了T淋巴细胞比例在阿尔茨海默病（AD）预后中的预测价值。通过一项涉及62例AD患者的回顾性研究，他们发现T淋巴细胞比例降低与预后较差相关，改良Rankin量表评分更高表明了这一点。虽然该研究突出了T淋巴细胞比例作为预后标志物的潜力，但它表明需要进行更大规模的多中心研究以提高普遍性和有效性。此外，未来的研究在评估预后时可以使用认知测试，并深入探究AD进展背后的免疫机制。尽管回顾性设计存在固有局限性，但白（等人）的工作有助于理解免疫系统在AD预后中的作用，为这一研究不足的领域的进一步探索铺平了道路。
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