Centre for Neuroscience, Indian Institute of Science, Bengaluru, India.
MS Ramaiah Medical College & Memorial Hospital, Bengaluru, India.
Elife. 2021 Jun 8;10:e61666. doi: 10.7554/eLife.61666.
Alzheimer's disease (AD) in elderly adds substantially to socioeconomic burden necessitating early diagnosis. While recent studies in rodent models of AD have suggested diagnostic and therapeutic value for gamma rhythms in brain, the same has not been rigorously tested in humans. In this case-control study, we recruited a large population (N = 244; 106 females) of elderly (>49 years) subjects from the community, who viewed large gratings that induced strong gamma oscillations in their electroencephalogram (EEG). These subjects were classified as healthy (N = 227), mild cognitively impaired (MCI; N = 12), or AD (N = 5) based on clinical history and Clinical Dementia Rating scores. Surprisingly, stimulus-induced gamma rhythms, but not alpha or steady-state visually evoked responses, were significantly lower in MCI/AD subjects compared to their age- and gender-matched controls. This reduction was not due to differences in eye movements or baseline power. Our results suggest that gamma could be used as a potential screening tool for MCI/AD in humans.
老年痴呆症（AD）给社会经济带来了巨大负担，因此需要早期诊断。虽然最近 AD 啮齿动物模型的研究表明大脑伽马节律具有诊断和治疗价值，但这在人类中尚未经过严格测试。在这项病例对照研究中，我们从社区招募了大量老年人（>49 岁）受试者（N=244；106 名女性），他们观看了大型光栅，这些光栅在他们的脑电图（EEG）中引起了强烈的伽马振荡。这些受试者根据临床病史和临床痴呆评定量表被分为健康组（N=227）、轻度认知障碍组（MCI；N=12）或 AD 组（N=5）。令人惊讶的是，与年龄和性别匹配的对照组相比，MCI/AD 受试者的刺激诱导的伽马节律明显降低，而阿尔法或稳态视觉诱发电位反应则没有。这种降低不是由于眼球运动或基线功率的差异造成的。我们的研究结果表明，伽马可能被用作人类 MCI/AD 的潜在筛查工具。
