Salem Mohammed Saleh E Khalifa, Alherek Abdul, Van Rooyen Martin, Mukendi Alain Mwamba
University of the Witwatersrand, Department of Surgery, Division of Urology Klerksdorp hospital Klerksdorp Northwest South Africa.
Clin Case Rep. 2024 Sep 16;12(9):e9444. doi: 10.1002/ccr3.9444. eCollection 2024 Sep.
Neuroendocrine tumors of the bladder are rare, accounting for less than 1% of all bladder tumors. Among these, large cell neuroendocrine carcinoma is an extremely uncommon subtype. We report on a histologically confirmed case of mixed both large and small cells neuroendocrine tumor of the bladder in a 64-year-old male with a history of bilharzial cystitis. The diagnosis was made after radical cystectomy with Immunohistochemical staining revealing positivity for synaptophysin, CD56, and AE1/3. While bilharzia is commonly linked to squamous cell carcinoma in the bladder, the potential relationship with neuroendocrine tumors is still relatively unexplored in this context. This case marks the first reported instance of the atypical coexistence of bilharzial cystitis and mixed large and small cell neuroendocrine carcinoma of the bladder. This unique case of coexisting highlights a rare phenomenon warranting further study. Similar associations have been documented in other organs, emphasizing the importance of exploring underlying mechanisms and clinical implications for improved patient care and outcomes.
膀胱神经内分泌肿瘤较为罕见，占所有膀胱肿瘤的比例不到1%。其中，大细胞神经内分泌癌是一种极其罕见的亚型。我们报告一例经组织学确诊的膀胱大细胞和小细胞混合型神经内分泌肿瘤病例，患者为一名64岁男性，有血吸虫性膀胱炎病史。诊断是在根治性膀胱切除术后作出的，免疫组织化学染色显示突触素、CD56和AE1/3呈阳性。虽然血吸虫病通常与膀胱鳞状细胞癌有关，但在这种情况下，其与神经内分泌肿瘤的潜在关系仍相对未被探索。该病例是首次报道的血吸虫性膀胱炎与膀胱大细胞和小细胞混合型神经内分泌癌非典型共存的病例。这种独特的共存病例突出了一种罕见现象，值得进一步研究。其他器官也有类似关联的记录，强调了探索潜在机制和临床意义以改善患者护理和治疗结果的重要性。
