Razuvayeva Yuliya, Kashapov Ruslan, Ziganshina Albina, Salnikov Vadim, Sapunova Anastasiia, Voloshina Alexandra, Zakharova Lucia
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia.
Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 2/31 Lobachevsky str., 420111, Kazan, Russia.
Chem Asian J. 2024 Dec 16;19(24):e202400709. doi: 10.1002/asia.202400709. Epub 2024 Oct 31.
In the present work, a simple supramolecular approach was used to spontaneously form nanoparticles from sodium carboxymethylcellulose and viologen calix[4]resorcinol as a result of joint self-assembly in water at room temperature. Supramolecular interactions between them led to the formation of nanoparticles, the morphology and properties of which depend on polymer/macrocycle ratio. When there is excess of macrocycle, the nanoparticles bind lipophilic oleic acid, and when there is excess of polymer, they bind hydrophilic doxorubicin. Interestingly, the solubilization of lipophilic quercetin into these nanoparticles was significantly increased compared to the pure polymer and macrocycle, regardless of their ratio. The nanoparticles of triple composition (polymer/macrocycle/drug) have a more effective penetration ability in tumorcells than those of double composition (polymer/drug). The presented results are the first step towards the creation of new nanotechnologies to improve the bioavailability and delivery of bioactive components.
在本研究中，采用一种简单的超分子方法，在室温下于水中通过羧甲基纤维素钠和紫精杯[4]间苯二酚的联合自组装自发形成纳米颗粒。它们之间的超分子相互作用导致纳米颗粒的形成，其形态和性质取决于聚合物/大环化合物的比例。当大环化合物过量时，纳米颗粒结合亲脂性油酸；当聚合物过量时，它们结合亲水性阿霉素。有趣的是，无论聚合物与大环化合物的比例如何，与纯聚合物和大环化合物相比，亲脂性槲皮素在这些纳米颗粒中的溶解度都显著提高。三元组合物（聚合物/大环化合物/药物）的纳米颗粒在肿瘤细胞中的渗透能力比二元组合物（聚合物/药物）的纳米颗粒更有效。所呈现的结果是朝着创造新的纳米技术以提高生物活性成分的生物利用度和递送迈出的第一步。
