Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
Curr Obes Rep. 2024 Dec;13(4):724-738. doi: 10.1007/s13679-024-00588-7. Epub 2024 Sep 17.
This narrative review summarizes current literature on the relationship of mitochondrial biomarkers with obesity-related characteristics, including body mass index and body composition.
Mitochondria, as cellular powerhouses, play a pivotal role in energy production and the regulation of metabolic process. Altered mitochondrial functions contribute to obesity, yet evidence of the intricate relationship between mitochondrial dynamics and obesity-related outcomes in human population studies is scarce and warrants further attention. We discuss emerging evidence linking obesity and related health outcomes to impaired oxidative phosphorylation pathways, oxidative stress and mtDNA variants, copy number and methylation, all hallmark of suboptimal mitochondrial function. We also explore the influence of dietary interventions and metabolic and bariatric surgery procedures on restoring mitochondrial attributes of individuals with obesity. Finally, we report on the potential knowledge gaps in the mitochondrial dynamics for human health for future study.
本文综述了当前关于线粒体生物标志物与肥胖相关特征（包括体重指数和身体成分）关系的文献。
线粒体作为细胞的动力源，在能量产生和代谢过程的调节中起着关键作用。线粒体功能的改变导致肥胖，但关于人类人群研究中线粒体动力学与肥胖相关结果之间复杂关系的证据很少，值得进一步关注。我们讨论了将肥胖和相关健康结果与受损的氧化磷酸化途径、氧化应激和 mtDNA 变体、拷贝数和甲基化联系起来的新证据，所有这些都是线粒体功能不佳的标志。我们还探讨了饮食干预和代谢及减重手术程序对恢复肥胖个体线粒体特性的影响。最后，我们报告了线粒体动力学对人类健康的潜在知识空白，以供未来研究。
