线粒体调节与白色脂肪组织稳态
Mitochondrial regulation and white adipose tissue homeostasis.
机构信息
Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
出版信息
Trends Cell Biol. 2022 Apr;32(4):351-364. doi: 10.1016/j.tcb.2021.10.008. Epub 2021 Nov 19.
Abstract
The important role of mitochondria in the regulation of white adipose tissue (WAT) remodeling and energy balance is increasingly appreciated. The remarkable heterogeneity of the adipose tissue stroma provides a cellular basis to enable adipose tissue plasticity in response to various metabolic stimuli. Regulating mitochondrial function at the cellular level in adipocytes, in adipose progenitor cells (APCs), and in adipose tissue macrophages (ATMs) has a profound impact on adipose homeostasis. Moreover, mitochondria facilitate the cell-to-cell communication within WAT, as well as the crosstalk with other organs, such as the liver, the heart, and the pancreas. A better understanding of mitochondrial regulation in the diverse adipose tissue cell types allows us to develop more specific and efficient approaches to improve adipose function and achieve improvements in overall metabolic health.
摘要
线粒体在调节白色脂肪组织（WAT）重塑和能量平衡方面的重要作用越来越受到重视。脂肪组织基质的显著异质性为脂肪组织对各种代谢刺激产生可塑性提供了细胞基础。调节脂肪细胞、脂肪祖细胞（APCs）和脂肪组织巨噬细胞（ATMs）中的线粒体功能对脂肪组织稳态具有深远影响。此外，线粒体促进 WAT 内的细胞间通讯，以及与其他器官（如肝脏、心脏和胰腺）的串扰。更好地理解不同脂肪组织细胞类型中线粒体的调节作用，使我们能够开发更具特异性和更有效的方法来改善脂肪功能，从而改善整体代谢健康。
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