Laboratory of Animal Pathology, Department of Preventive Veterinary Medicine, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, PR 445 Km 380, Campus Universitário, Londrina, Paraná, 86057-970, Brazil.
Multi-User Animal Health Laboratory (LAMSA), Department of Preventive Veterinary Medicine, Universidade Estadual de Londrina, Paraná, Brazil.
Vet Res Commun. 2024 Dec;48(6):4133-4139. doi: 10.1007/s11259-024-10529-3. Epub 2024 Sep 17.
Although there are several studies that described the possible participation of Mycoplasmopsis bovirhinis (formerly, Mycoplasma bovirhinis) in respiratory disease in calves worldwide, none of these evaluated the effects of concomitant infections on the shedding of this organism. Accordingly, this study evaluated the effects of simultaneous respiratory infections in dairy calves on the nasal shedding of M. bovirhinis. A statistical two-step model, using univariable and multivariable with logistic regression was developed to investigate and predict the possible effects of simultaneous infections by Histophilus somni, Mannheimia haemolytica, Pasteurella multocida, bovine coronavirus (BCoV), and ovine gammaherpesvirus 2 (OvGHV2) in dairy calves on the nasal shedding of M. bovirhinis. The multivariable analysis demonstrated that dairy calves infected with OvGHV2 have 2.59 times likelihood of nasal shedding of M. bovirhinis relative to calves not infected by OvGHV2, while the odds of nasal shedding of M. bovirhinis was 3.46 times higher in dairy calves infected by M. haemolytica. In contrast, simultaneous respiratory infections in dairy calves by H. somni, P. multocida, and BCoV had no direct effect on the nasal shedding of M. bovirhinis. Consequently, infections by OvGHV2 and M. haemolytica may be possible risk factors for the nasal shedding of M. bovirhinis in dairy calves. These results demonstrated the importance of disease modeling in veterinary medicine to predict and understand the complex outcomes of associations in animals concomitantly infected by several disease pathogens.
尽管有几项研究描述了 Mycoplasmopsis bovirhinis（以前称为 Mycoplasma bovirhinis）在全球范围内的小牛呼吸道疾病中的可能参与，但这些研究都没有评估伴随感染对该生物体脱落的影响。因此，本研究评估了同时发生的呼吸道感染对奶牛犊牛鼻分泌物中 Mycoplasmopsis bovirhinis 的影响。使用单变量和多变量逻辑回归建立了一个统计两步模型，以研究和预测同时感染胸膜肺炎放线杆菌、溶血性曼海姆菌、多杀性巴氏杆菌、牛冠状病毒（BCoV）和绵羊γ疱疹病毒 2（OvGHV2）对奶牛犊牛鼻分泌物中 Mycoplasmopsis bovirhinis 脱落的可能影响。多变量分析表明，感染绵羊γ疱疹病毒 2 的奶牛犊牛鼻分泌物中 Mycoplasmopsis bovirhinis 的可能性是未感染绵羊γ疱疹病毒 2 的奶牛犊牛的 2.59 倍，而感染溶血性曼海姆菌的奶牛犊牛鼻分泌物中 Mycoplasmopsis bovirhinis 的可能性则高出 3.46 倍。相比之下，同时感染胸膜肺炎放线杆菌、多杀性巴氏杆菌和牛冠状病毒对奶牛犊牛鼻分泌物中 Mycoplasmopsis bovirhinis 的脱落没有直接影响。因此，绵羊γ疱疹病毒 2 和溶血性曼海姆菌的感染可能是奶牛犊牛鼻分泌物中 Mycoplasmopsis bovirhinis 脱落的可能危险因素。这些结果表明，在兽医医学中进行疾病建模对于预测和理解同时感染几种疾病病原体的动物中关联的复杂结果非常重要。
