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The primary cilium of cholinergic neurons may be a linchpin in the progression of Parkinson's Disease.

作者信息

Uribe-Cano Santiago, Kottmann Andreas H

机构信息

City University of New York (CUNY) Graduate Center, Neuroscience Collaborative, New York, NY 10016.

Department of Molecular, Cellular and Biomedical Sciences, The City University of New York (CUNY) School of Medicine, New York, NY 10031.

出版信息

Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2414226121. doi: 10.1073/pnas.2414226121. Epub 2024 Sep 17.

DOI:10.1073/pnas.2414226121
PMID:39288184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11441531/
Abstract
摘要

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本文引用的文献

1
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease.原发性纤毛缺失与致病性LRRK2驱动的和特发性帕金森病中的多巴胺能神经保护作用
Proc Natl Acad Sci U S A. 2024 Aug 6;121(32):e2402206121. doi: 10.1073/pnas.2402206121. Epub 2024 Aug 1.
2
Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis.PPM1H 磷酸酶的定位调节帕金森病相关 LRRK2 激酶介导的 Rab GTP 酶磷酸化和纤毛发生。
Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2315171120. doi: 10.1073/pnas.2315171120. Epub 2023 Oct 27.
3
Perspective on the current state of the LRRK2 field.
对富含亮氨酸重复激酶2（LRRK2）领域当前状况的展望。
NPJ Parkinsons Dis. 2023 Jul 1;9(1):104. doi: 10.1038/s41531-023-00544-7.
4
Primary cilia as dynamic and diverse signalling hubs in development and disease.原发性纤毛作为发育和疾病中动态多样的信号枢纽。
Nat Rev Genet. 2023 Jul;24(7):421-441. doi: 10.1038/s41576-023-00587-9. Epub 2023 Apr 18.
5
Cellular and molecular mechanisms of Hedgehog signalling.Hedgehog 信号通路的细胞与分子机制。
Nat Rev Mol Cell Biol. 2023 Sep;24(9):668-687. doi: 10.1038/s41580-023-00591-1. Epub 2023 Mar 17.
6
Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain.致病性 LRRK2 对小鼠脑神经元和星形胶质细胞中的初级纤毛和 Hedgehog 信号的调控。
Elife. 2021 Oct 18;10:e67900. doi: 10.7554/eLife.67900.
7
Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia.多巴胺能共传递与 sonic hedgehog 抑制帕金森病模型和 L-Dopa 诱导的运动障碍中的异常不自主运动。
Commun Biol. 2021 Sep 22;4(1):1071. doi: 10.1038/s42003-021-02567-3.
8
New Insights Into Cholinergic Neuron Diversity.对胆碱能神经元多样性的新见解
Front Mol Neurosci. 2019 Aug 27;12:204. doi: 10.3389/fnmol.2019.00204. eCollection 2019.
9
Dopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson's Disease.多巴胺缺乏症降低帕金森病模型纹状体胆碱能中间神经元功能。
Neuron. 2019 Sep 25;103(6):1056-1072.e6. doi: 10.1016/j.neuron.2019.06.013. Epub 2019 Jul 16.
10
Substantia nigra dopaminergic neurons and striatal interneurons are engaged in three parallel but interdependent postnatal neurotrophic circuits.黑质多巴胺能神经元和纹状体中间神经元参与了三个平行但相互依赖的出生后神经营养回路。
Aging Cell. 2018 Oct;17(5):e12821. doi: 10.1111/acel.12821. Epub 2018 Jul 30.