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骨软化症双侧股骨干骨折:一例报告及文献复习

Bilateral femoral shaft fractures in osteomalacia: A case report and literature review.

作者信息

Khan Abdul Rehman, Rehan Fatima, Nasrumminallah Maryam, Kumar Harendra

机构信息

Dow University of Health Sciences, Karachi, Pakistan.

Dow University of Health Sciences, Karachi, Pakistan.

出版信息

Int J Surg Case Rep. 2024 Oct;123:110302. doi: 10.1016/j.ijscr.2024.110302. Epub 2024 Sep 15.

Abstract

INTRODUCTION AND IMPORTANCE

When two non-traumatic femoral shaft fractures happen at the same time, they are usually not caused by high-energy trauma or medical conditions like osteomalacia caused by poor nutrition, long-term bisphosphonate medication use, or steroid use. Because this phenomenon is connected to inadequate bone mineralization and bone metabolism, it occurs when a bone is consistently under high stress.

CASE PRESENTATION

A 40-year-old lady with a medical history of osteomalacia, including continuous vitamin D replacement therapy, showed up at the emergency room complaining of discomfort and swelling in her right thigh caused by a fall. During the emergency examination, X-rays showed a subtrochanteric fracture with a short oblique fracture line and a displaced oblique fracture in the right femoral shaft, but no fragmentation in the left femoral shaft. Osteomalacia caused the bilateral femoral shaft fracture in which the patient was identified as being displaced. We planned a surgical correction that included a closed reduction with intramedullary nailing and distal static screws on the right side, as well as intramedullary nailing followed by locking screw insertion on the left. Following the operation, the avoidance of bisphosphonate medications gained precedence.

CLINICAL DISCUSSION

Patients of any age who come with bone pain, non-traumatic fractures, and muscle weakness should have their blood vitamin D, ALP levels, and BMD evaluated for osteomalacia. If a conventional X-ray shows normal, an MRI or bone scan of both hips is recommended to rule out any underlying fatigue fractures. Finding and treating the underlying cause of osteomalacia can help improve the prediction.

CONCLUSION

Intramedullary nailing with screws is the most effective treatment for femoral shaft fractures. Improving patient outcomes relies on identifying and treating the underlying cause of osteomalacia. Given the patient's history and condition, avoiding bisphosphonate medicines following surgery was a primary priority in this case.

摘要

引言与重要性

当同时发生两处非创伤性股骨干骨折时,通常并非由高能量创伤或诸如营养不良导致的骨软化症、长期使用双膦酸盐药物或类固醇药物等医学状况引起。由于这种现象与骨矿化不足和骨代谢有关,它发生在骨骼持续承受高应力的情况下。

病例介绍

一名40岁女性,有骨软化症病史,包括持续的维生素D替代治疗,因跌倒后出现右大腿不适和肿胀而到急诊室就诊。急诊检查时,X线显示右股骨转子下骨折,有短斜形骨折线,右股骨干有移位的斜形骨折,但左股骨干无骨折碎片。骨软化症导致了双侧股骨干骨折,该患者被确定为移位骨折。我们计划进行手术矫正,包括右侧闭合复位髓内钉固定及远端静力螺钉固定,以及左侧髓内钉固定后锁定螺钉置入。术后,避免使用双膦酸盐药物成为首要事项。

临床讨论

任何年龄出现骨痛、非创伤性骨折和肌肉无力的患者,都应评估其血液维生素D、碱性磷酸酶水平和骨密度以排查骨软化症。如果常规X线显示正常,建议进行双髋MRI或骨扫描以排除任何潜在的疲劳骨折。找到并治疗骨软化症的潜在病因有助于改善预后。

结论

带螺钉的髓内钉固定是股骨干骨折最有效的治疗方法。改善患者预后依赖于识别和治疗骨软化症的潜在病因。鉴于患者的病史和病情,本病例术后避免使用双膦酸盐药物是首要任务。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b79/11420458/8514b15fc024/gr1.jpg

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