硝酸铀酰中毒下的肺泡伤口愈合改变

Alveolar wound healing alteration under uranyl nitrate intoxication.

作者信息

Guglielmotti M B, Ubios A M, Cabrini R L

出版信息

J Oral Pathol. 1985 Aug;14(7):565-72. doi: 10.1111/j.1600-0714.1985.tb00530.x.

DOI:10.1111/j.1600-0714.1985.tb00530.x

Abstract

The deposit of uranium compounds in calcifying zones has been demonstrated in bone. Nevertheless, no studies on the effect of uranium on osteogenesis have been performed. A histologic and histometric study of the effect of a single intraperitoneal injection of 2 mg/kg of body weight of uranyl nitrate on bone formation is presented. It was performed on rats' healing sockets, 14 days after tooth extraction. The alveolar bone volume (15 X 10(5) micron vs. 34 X 10(5) micron2), total bone formation areas (4.85% vs. 19.55%), and volume density of bone in the alveolar apical third (0.26 vs. 0.40) were significantly lower in intoxicated animals than in the controls. These results indicate the inhibitory effect of uranyl nitrate on bone formation.

摘要

铀化合物在骨骼钙化区的沉积已在骨骼中得到证实。然而，尚未有关于铀对骨生成影响的研究。本文呈现了一项组织学和组织计量学研究，该研究针对单次腹腔注射2mg/kg体重硝酸铀酰对骨形成的影响展开。研究在大鼠拔牙后14天的愈合牙槽窝上进行。中毒动物的牙槽骨体积（15×10⁵微米对34×10⁵微米²）、总骨形成面积（4.85%对19.55%）以及牙槽顶三分之一处的骨体积密度（0.26对0.40）均显著低于对照组。这些结果表明硝酸铀酰对骨形成具有抑制作用。