Ubios A M, Guglielmotti M B, Cabrini R L
Faculty of Dentistry, University of Buenos Aires, Argentina.
Arch Environ Health. 1990 Nov-Dec;45(6):374-7. doi: 10.1080/00039896.1990.10118758.
The beneficial effect of ethane 1-hydroxy-1, 1-diphosphonate (EHDP) in restoring the inhibition of bone formation in cases of acute uranium intoxication is presented. Bone formation was studied histomorphometrically in a model of alveolar bone healing. After tooth extraction, 40 rats were divided into 4 groups that received (1) no further treatment, (2) 10 daily intraperitoneal injections of 7.5 mg/kg of body weight of EHDP, (3) an intraperitoneal injection of 2.0 mg/kg of body weight of uranyl nitrate, and (4) the same treatment as was provided rats in groups 2 and 3. The results showed that the healing of bone did not occur in exposed animals, whereas healing in EHDP-treated exposed animals did not differ from that of nonexposed controls. This effect might result from a blocking and/or competitive action of EHDP and/or the stimulation that EHDP elicits at the doses and in the administration period studied.
本文介绍了乙烷1-羟基-1,1-二膦酸酯（EHDP）在恢复急性铀中毒病例中对骨形成抑制作用方面的有益效果。在牙槽骨愈合模型中，采用组织形态计量学方法研究骨形成情况。拔牙后，将40只大鼠分为4组，分别接受以下处理：（1）不进行进一步处理；（2）每天腹腔注射10次，每次剂量为7.5mg/kg体重的EHDP；（3）腹腔注射一次，剂量为2.0mg/kg体重的硝酸铀酰；（4）与第2组和第3组大鼠接受相同的处理。结果表明，暴露组动物的骨愈合未发生，而经EHDP处理的暴露组动物的愈合情况与未暴露对照组无差异。这种效果可能是由于EHDP的阻断和/或竞争作用，以及在研究的剂量和给药期间EHDP所引发的刺激作用。
