言语功能在基底神经节中是否存在偏侧化？来自新发帕金森病的证据。
Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinson's disease.
作者信息
Rusz Jan, Dusek Petr, Tykalova Tereza, Novotny Michal, Illner Vojtech, Simek Michal, Kouba Tomas, Kryze Petr, Zogala David, Ruzicka Evzen, Sousa Mário, Jorge Adriana, Nef Tobias, Krack Paul
机构信息
Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic
Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
出版信息
J Neurol Neurosurg Psychiatry. 2025 Apr 10;96(5):462-465. doi: 10.1136/jnnp-2024-334297.
BACKGROUND
Research on the possible influence of lateralised basal ganglia dysfunction on speech in Parkinson's disease is scarce. This study aimed to compare speech in de-novo, drug-naive patients with Parkinson's disease (PD) with asymmetric nigral dopaminergic dysfunction, predominantly in either the right or left hemisphere.
METHODS
Acoustic analyses of reading passages were performed. Asymmetry of nigral dysfunction was defined using dopamine transporter-single-photon emission CT (DAT-SPECT).
RESULTS
From a total of 135 de novo patients with PD assessed, 47 patients had a lower right and 36 lower left DAT availability in putamen based on DAT-SPECT. Patients with PD with lower left DAT availability had higher dysarthria severity via composite dysarthria index compared with patients with lower right DAT availability (p=0.01).
CONCLUSION
Our data support the crucial role of DAT availability in the left putamen in speech. This finding might provide important clues for managing speech following deep brain stimulation.
背景
关于帕金森病中基底神经节功能不对称性障碍对言语可能产生的影响的研究较少。本研究旨在比较新发、未接受过药物治疗且存在不对称性黑质多巴胺能功能障碍（主要累及右侧或左侧半球）的帕金森病（PD）患者的言语情况。
方法
对阅读段落进行声学分析。使用多巴胺转运体单光子发射计算机断层扫描（DAT-SPECT）来定义黑质功能障碍的不对称性。
结果
在总共评估的135例新发PD患者中，基于DAT-SPECT，47例患者壳核的右侧DAT可用性较低，36例患者壳核的左侧DAT可用性较低。与右侧DAT可用性较低的患者相比，左侧DAT可用性较低的PD患者通过综合构音障碍指数评估的构音障碍严重程度更高（p=0.01）。
结论
我们的数据支持左侧壳核中DAT可用性在言语中的关键作用。这一发现可能为深部脑刺激术后言语管理提供重要线索。
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